Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Nuclear receptor Nurr1, a NR4 Nerve Growth Factor-Like Receptor, has been shown to affect the maturation, migration, striatal target area innervation, and survival of differentiating mesencephalic dopaminergic (DA) neurons. It has been shown that the receptor tyrosine kinase Ret1 is regulated by Nurr1 in midbrain dopamine neurons. Nurr1 binds to target DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors).