Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Schizophrenia-like features in transgenic mice overexpressing human HO-1 in the astrocytic compartment. Song W, Zukor H, Lin SH, Hascalovici J, Liberman A, Tavitian A, Mui J, Vali H, Tong XK, Bhardwaj SK, Srivastava LK, Hamel E, Schipper HM. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012 32:10841-53.
Nuclear receptor Nurr1, a NR4 Nerve Growth Factor-Like Receptor, has been shown to affect the maturation, migration, striatal target area innervation, and survival of differentiating mesencephalic dopaminergic (DA) neurons. It has been shown that the receptor tyrosine kinase Ret1 is regulated by Nurr1 in midbrain dopamine neurons. Nurr1 binds to target DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors).
Formalin-fixed and paraffin-embedded human brain tissue reacted with NURR1 (NR4A2) antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Confocal immunofluorescence of NURR1 (NR4A2) Antibody with HeLa cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
NR4A2 Antibody western blot of HeLa cell line lysates (35 ug/lane). The NR4A2 antibody detected the NR4A2 protein (arrow).
Western blot of anti-NURR1(NR4A2) antibody in mouse brain tissue lysate. NURR1(NR4A2) (arrow) was detected using the purified antibody.