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NR4A1 / NUR77
nuclear receptor subfamily 4, group A, member 1
Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases.
| Gene Name: | nuclear receptor subfamily 4, group A, member 1 |
| Family/Subfamily: | NHR , NR4 Nerve growth factor-like |
| Synonyms: | NR4A1, GFRP1, Early response protein NAK1, HMR, NGFIB, Orphan nuclear receptor TR3, Orphan receptor tr3, Steroid receptor TR3, TR3, NAK1, NGFI-B, NP10, Receptor NGFIB, Testicular receptor 3, TR3 orphan receptor, N10, NAK-1, NUR77, Orphan nuclear receptor HMR |
| Target Sequences: | NM_002135 NP_002126.2 P22736 |
Publications (6)
1
Deficiency of the NR4A neuron-derived orphan receptor-1 attenuates neointima formation after vascular injury. Nomiyama T, Zhao Y, Gizard F, Findeisen HM, Heywood EB, Jones KL, Conneely OM, Bruemmer D. Circulation. 2009 119:577-86. (WB, IHC-P; Mouse)
[Full Text Article]
[PubMed:19153266]
[PMC:PMC2748681]
2
Mitochondrial translocation of Nur77 mediates cardiomyocyte apoptosis. Cheng Z, Vlkers M, Din S, Avitabile D, Khan M, Gude N, Mohsin S, Bo T, Truffa S, Alvarez R, Mason M, Fischer KM, Konstandin MH, Zhang XK, Heller Brown J, Sussman MA. European heart journal. 2011 32:2179-88. (ICC, IHC-P; Mouse, Rat)
[Full Text Article]
[PubMed:21228009]
[PMC:PMC3164102]
3
NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin gene: analysis of TRH knockout mice. Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, Hashimoto K, Saito T, Tsuchiya T, Okada S, Satoh T, Mori M. PloS one. 2012 7:e40437. (ICC, WB, IHC-P, ChrIP; Mouse, Human, Rat)
[Full Text Article]
[PubMed:22792320]
[PMC:PMC3392219]
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NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa251-266) Antibody
Mouse, Rat, Human
ChrIP, ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
Fast Shipping
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (Internal) Antibody
Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Hamster, Human
IHC, IHC-P
Unconjugated
50 µg/$440
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa317-366) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NR4A1 / NUR77 Goat anti-Human Polyclonal (aa401-414) Antibody
Rabbit, Mouse, Dog, Rat, Hamster, Horse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
NR4A1 / NUR77 Rabbit anti-Human Monoclonal (pSer351) (11C1052) Antibody
Human
WB
Unconjugated
100 µl/$763
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (pSer351) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$893
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (Gly347) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa99-112) Antibody
Rabbit, Mouse, Guinea pig, Sheep, Bovine, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
10 µg/$318; 100 µg/$470
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
Fast Shipping
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
NR4A1 / NUR77 Mouse anti-Human Monoclonal (NR4AB9G12) Antibody
Human
DB, ICC, IF, WB
Unconjugated
100 µg/$486
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa324-373) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa324-373) (FITC) Antibody
Rabbit, Dog, Guinea pig, Bovine, Horse, Orangutan, Gibbon, Human, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (290-370 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (pSer351) (APC) Antibody
Human
DB, ELISA
APC Conjugated
200 µl/$952
NR4A1 / NUR77 Rabbit anti-Human Polyclonal Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
50 µl/$460
HEK 293 Cells
Myc-DDK (Flag)
64.3 kDa
20 µg/$1,107
NR4A1 / NUR77 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (p351) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
NR4A1 / NUR77 Mouse anti-Human Monoclonal (NR4AB9G12) Antibody
Human
DB, ICC, WB
Unconjugated
100 µg/$965
NR4A1 / NUR77 Rabbit anti-Human Polyclonal (aa1-170) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
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