Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig, Rabbit
IHC - Paraffin, Western blot
Rabbit Polyclonal (IgG) to Human NR1I3 / CAR
Western blot, Immunoprecipitation
Human NR1I3 / CAR
Human (tested or 100% immunogen sequence identity)
Western blot (1:500 - 1:1000)
Immunoprecipitation (1:50 - 1:200)
Specificity and Use
NR1I3 / CAR antibody was raised against amino acids 90-140 (Accession # Q14994).
Recognizes endogenous levels of human CAR.
Suitable for use in Western Blot and Immunoprecipitation. Immunoprecipitation: 1:50-1:200. Western Blot: 1:500-1:1000.
PBS, pH 7.2, 15 mM sodium azide
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C.
NR1I3 Antibody, Car-beta Antibody, CAR1 Antibody, Constitutive active receptor Antibody, Constitutive active response Antibody, Orphan nuclear receptor MB67 Antibody, MB67 Antibody, CAR Antibody
NR1I3 / CAR is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members.