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NR1H4 / FXR
nuclear receptor subfamily 1, group H, member 4
Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol. In the intestine, binding of bile acids to the RXR/FXR complex activates the intestinal bile acid-binding protein (IBABP) and results in increased recycling of bile acids. A pseudogene of FXR, located on chromosome 1 (1p13.1 - 1p13.3), has been identified recently using a comparative genomics approach.
| Gene Name: | nuclear receptor subfamily 1, group H, member 4 |
| Family/Subfamily: | NHR , NR1 Thyroid hormone-like |
| Synonyms: | NR1H4, BAR, Farnesyl x receptor, FXR, HRR1, Farnesoid x activated receptor, Farnesoid X receptor, Farnesol receptor HRR-1, HRR-1, RXR-interacting protein 14, RIP14, Bile acid receptor, Farnesoid X nuclear receptor, Farnesoid X-activated receptor |
| Target Sequences: | NM_005123 NP_005114.1 Q96RI1 |
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NR1H4 / FXR Rabbit anti-Human Polyclonal (aa194-243) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa194-243) (HRP) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa194-243) (Biotin) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa194-243) (FITC) Antibody
Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NR1H4 / FXR Mouse anti-Human Monoclonal (aa2-126) Antibody
Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$941
NR1H4 / FXR Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$294; 100 µl/$360
NR1H4 / FXR Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$854
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa18-46) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa18-46) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
200 µl/$952
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa18-46) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa18-46) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa18-46) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa18-46) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
NR1H4 / FXR Goat anti-Human Polyclonal (aa251-264) Antibody
Dog, Bovine, Hamster, Pig, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa33-82) Antibody
Human
WB
Unconjugated
100 µl/$424
NR1H4 / FXR Rabbit anti-Human Polyclonal (aa323-372) Antibody
Human
WB
Unconjugated
100 µl/$424
NR1H4 / FXR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
0.1 ml/$386
E. coli
His-SUMO
62.2 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
NR1H4 / FXR Mouse anti-Human Monoclonal (aa21-297) (OTI4F12) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
NR1H4 / FXR Mouse anti-Human Monoclonal (aa21-297) (Carrier-free) (OTI4F12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
NR1H4 / FXR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
NR1H4 / FXR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µl/$332
NR1H4 / FXR Rabbit anti-Human Polyclonal Antibody
Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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