LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us
NR1H4 / FXR Antibody (aa33‑82) LS‑C205753
Antibody
FXR antibody LS-C205753 is an unconjugated rabbit polyclonal antibody to FXR (NR1H4) from human, horse, monkey and other species. Validated for WB.
Catalog
Size
Price
LS-C205753-50
50 µg (1 mg/ml)
Unavailable

Popular NR1H4 / FXR Products

Detection of FXR in HeLa nuclear extract using LS-C2784. ECL 30 minute detection.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: Western blot
Antibody
Species: Human, Rat
Applications: IHC, Western blot, Immunoprecipitation, ELISA
Anti-NR1H4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B987 concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig
Applications: IHC, IHC - Paraffin, Western blot
NR1H4 antibody LS-C107782 Western blot of THP-1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Guinea pig
Applications: Western blot

Product Description

FXR antibody LS-C205753 is an unconjugated rabbit polyclonal antibody to FXR (NR1H4) from human, horse, monkey and other species. Validated for WB.
About NR1H4 / FXR
Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol. Q96RI1 NM_005123 NP_005114.1

NR1H4 Antibody, BAR Antibody, Farnesyl x receptor Antibody, FXR Antibody, HRR1 Antibody, Farnesoid x activated receptor Antibody, Farnesoid X receptor Antibody, Farnesol receptor HRR-1 Antibody, HRR-1 Antibody, RXR-interacting protein 14 Antibody, RIP14 Antibody, Bile acid receptor Antibody, Farnesoid X nuclear receptor Antibody, Farnesoid X-activated receptor Antibody


Specifications

Target
Human NR1H4 / FXR
Host
Rabbit
Reactivity
Human, Monkey, Horse, Pig, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Mouse, Bovine, Dog (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with Biotin, FITC, HRP.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot
  • (applications tested for the base form of this product only)
Immunogen
NR1H4 / FXR antibody was raised against synthetic peptide located between aa33-82 of human NR1H4 (G8JLB0). Percent identity by BLAST analysis: Human, Chimpanzee, Gibbon, Monkey, Rabbit, Horse, Pig (100%); Mouse, Dog, Bovine (92%).
Epitope
aa33-82
Specificity
Human NR1H4 / FXR
Presentation
Lyophilized from PBS, 2% sucrose.
Reconstitution
50 µl Distilled water
Storage
Short term: 4°C; Long term: -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (0)


Customer Reviews (0)


Requested From: 
Date Requested: 6/24/2018

Get Social With Us! Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy



Catalog Number