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NR1A2 / THRB

thyroid hormone receptor, beta

Thyroid hormone receptor beta (TR beta), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect cholesterol metabolism, hearing, cone development in the eye, and hypothalamopituitary-thyroid axis function. Mice lacking the TR beta locus exhibit elevated thyroid hormone levels, profound hearing loss, impaired weight gain, abnormal bone development, and loss of thyroid-hormone induced activation of cholesterol 7 alpha-hydroxylase (CYP7A). Mutation in the ligand-binding domain of TR beta has been linked to the genetic disorder Resistance to Thyroid Hormone (RTH), and possibly to human cone disorders. Congenital thyroid disorders that impair hearing and result in profound deafness are common in geographic areas with a prevalence of iodine deficiency. Two human TR beta protein isoforms have been identified: TR beta1 (461 aa), TR beta2 (476 aa). Two additional protein isoforms, TR beta3 (390 aa), and a non-DNA binding TR deltabeta3 (288 aa), have been documented in rat.

Gene Name: thyroid hormone receptor, beta
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: THRB, C-erba beta2, C-ERBA-2, ERBA-BETA, GRTH, Oncogene ERBA2, THRB2, TR-BETA, THRB1, NR1A2, Thyroid hormone receptor beta, Trbeta1, Trbeta2, C-erba beta1, C-ERBA-BETA, ERBA2, PRTH, THR1, Thyroid hormone receptor, beta, Trbeta
Target Sequences: NM_000461 NP_000452.2 P10828

☰ Filters
Antibodies (53)
Proteins (11)
ELISA Kits (6)
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DNA Binding (1)
Over-Expression Lysate (6)
Primary (53)
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NR1A2 / THRB (70)
Human (47)
Mouse (28)
Rat (29)
Bat (3)
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Chimpanzee (12)
Dog (7)
Gibbon (12)
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Hamster (1)
Horse (7)
Monkey (13)
Pig (9)
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IHC (18)
IHC-P (11)
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rabbit (51)
goat (2)
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aa239-457 (8)
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aa37-86 (4)
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30-110 aa, N-terminal (1)
90-170 aa (1)
Leu37 (1)
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aa183-199 (1)
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No (70)
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NR1A2 / THRB Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Thyroid Hormone Receptor beta Antibody. The picture on the right is blocked with the synthesized peptide.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa11-60) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NR1A2 / THRB Antibody - Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE)
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NR1A2 / THRB Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$450
NR1A2 / THRB Antibody - 1:100 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NR1A2 / THRB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NR1A2 / THRB Antibody - Western blot analysis of the lysates from RAW264.7cells using THRB antibody.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa378-427) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NR1A2 / THRB Antibody - Western blot of 293 cell lysate using THR1 Antibody
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NR1A2 / THRB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
NR1A2 / THRB Antibody - Immunohistochemistry of paraffin-embedded human thyroid tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa1-461) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
NR1A2 / THRB Antibody - Immunohistochemistry of paraffin-embedded human thyroid tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa1-461) (HRP) Antibody
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
NR1A2 / THRB Antibody - Immunohistochemistry of paraffin-embedded human thyroid tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa1-461) (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
NR1A2 / THRB Antibody - Immunohistochemistry of paraffin-embedded human thyroid tissue using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa1-461) (FITC) Antibody
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
NR1A2 / THRB Antibody - Anti-THRB antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa37-86) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NR1A2 / THRB Antibody - Anti-THRB antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa37-86) (HRP) Antibody
Rabbit, Dog, Guinea pig, Rat, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NR1A2 / THRB Antibody - Anti-THRB antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa37-86) (Biotin) Antibody
Rabbit, Dog, Guinea pig, Rat, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NR1A2 / THRB Antibody - Anti-THRB antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (aa37-86) (FITC) Antibody
Rabbit, Dog, Guinea pig, Rat, Pig, Horse, Gibbon, Chimpanzee, Human, Monkey
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
NR1A2 / THRB Antibody - Anti-THRB1 Antibody - Western Blot. Western blot of affinity purified anti-THRB1 antibody shows detection of in vitro translated THRB1 (lane 2) and human thyroid stable cell line expressing THTRb1 (lane 3). No staining is evident in non transfected human thyroid cells (lane 1), over expressed THRA (lane 4) or HeLa stable cell line expressing THRA1 (lane 5). The band at ~62 kD, indicated by the arrowheads, corresponds to THRB. Personal communication, H. Ying, NCI, Bethesda, MD.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
ELISA, IF, IP, WB
Unconjugated
100 µg/$567
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NR1A2 / THRB Rabbit anti-Human Polyclonal (30-110 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NR1A2 / THRB Antibody - Peptide - + Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Thyroid Hormone Receptor ß antibody.
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NR1A2 / THRB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
NR1A2 / THRB Antibody - Immunohistochemistry of paraffin-embedded human esophageal cancer using THRB antibody at dilution of 1:200 (x400 lens)
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NR1A2 / THRB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NR1A2 / THRB Antibody - IHC of Thyroid Hormone Receptor (L37) pAb in paraffin-embedded human lung carcinoma tissue.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (Leu37) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
NR1A2 / THRB Antibody - Immunohistochemical analysis of THRB staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
NR1A2 / THRB Antibody - Immunofluorescence analysis of U-2OS cells using THRB Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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NR1A2 / THRB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
NR1A2 / THRB Rabbit anti-Human Polyclonal (90-170 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NR1A2 / THRB Antibody - Western blot analysis of extracts from 293 cells, treated with PMA (125ng/ml, 30mins), using TR-ß1 (Phospho-Ser142) antibody.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (pSer142) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
NR1A2 / THRB Antibody - Western blot analysis of lysates from 293 cells treated with PMA 125ng/ml 30', using TR-beta1 (Phospho-Ser142) Antibody. The lane on the right is blocked with the phospho peptide.
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NR1A2 / THRB Rabbit anti-Human Polyclonal (pSer142) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NR1A2 / THRB Antibody - Antibody (0.3 ug/ml) staining of Human Bone Marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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NR1A2 / THRB Goat anti-Human Polyclonal (aa216-227) Antibody
Rabbit, Mouse, Dog, Rat, Hamster, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$493
NR1A2 / THRB Antibody - SP2/0 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NR1A2 / THRB Rabbit anti-Mouse Polyclonal (aa71-120) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
Viewing 1-25 of 70 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).