Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Western blot, Immunoprecipitation, Flow Cytometry, ELISA, Functional Assay
Human NR1A2 / THRB
Human (tested or 100% immunogen sequence identity)
Protein G purified
Western blot (5 - 10 µg/ml)
Immunoprecipitation (5 - 10 µg/ml)
IHC - Paraffin
Specificity and Use
NR1A2 / THRB antibody was raised against recombinant Human Thyrotrophin receptor.
The thyrotrophin receptor is an important molecule in controlling the growth and function of the normal thyroid. Recognizes both native and denatured human thyrotrophin receptor aa354-359. Reacts with the mutant thyrotrophin receptor known as I167N as well as the wild type molecule. Inhibits binding of TSH. Does not crossreact with related LH and FSH receptors.
Immunoprecipitation: 5-10 ug/ml. Western Blot: 5-10 ug/ml. Flow Cytometry. ELISA.
Thyroid hormone receptor beta (TR beta), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect cholesterol metabolism, hearing, cone development in the eye, and hypothalamopituitary-thyroid axis function. Mice lacking the TR beta locus exhibit elevated thyroid hormone levels, profound hearing loss, impaired weight gain, abnormal bone development, and loss of thyroid-hormone induced activation of cholesterol 7 alpha-hydroxylase (CYP7A).