Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse (tested or 100% immunogen sequence identity)
Rat (at least 90% immunogen sequence identity)
Western blot (0.1 - 0.2 µg/ml)
ELISA (0.5 - 1 µg/ml)
Specificity and Use
NPRA / NPR1 antibody was raised against nS0-derived recombinant mouse Natriuretic Peptide Receptor A extracellular domain (aa29-469) Accession # P18293.
Recognizes mouse NPR-A.
Suitable for use in Western Blot and ELISA. Western Blot: 0.1-0.2 ug/ml. Detection limit is ~10 ng/lane under non-reducing and reducing conditions. Direct ELISA: 0.5-1 ug/ml. Detection limit is ~0.5 ng/well.
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain.