Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Protein A purified
Specificity and Use
NPPB / BNP antibody was raised against synthetic peptide: RPTGVWKSREVATEGI, corresponding to amino acids 46 - 61 of Human proBNP. Epitope: aa 46-61. Percent identity by BLAST analysis: Human (100%); Gibbon (88%); Marmoset (81%).
Species cross-reactivity: Cross-reacts with Human.
NPPB Antibody, BNP Antibody, Natriuretic peptides B Antibody, Natriuretic peptide B Antibody, Natriuretic protein Antibody, Brain type natriuretic peptide Antibody
NPPB / BNP is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure.