Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Specificity and Use
NPPA / ANP antibody was raised against human atrial natriuretic polypeptide covalently attached onto a carrier protein.
Recognizes Atrial Natriuretic Polypeptide (human) and the reactivity of Atrial Natriuretic Polypeptide (rat) is ~60%. Does not react to ACTH, Calcitonin (salmon), PTH (human 1-84) and Vasoactive Intestinal Peptide.
Suitable for use in RIA and Immunoprecipitation. Immunoprecipitation: 1 ug/mg of total cell protein (~10^7 cells).
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.