Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 23/1] (IgG1) to Human NPPA / ANP
IHC - Paraffin, Radioimmunoassay
Human NPPA / ANP
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [23/1]
Protein A purified
IHC - Paraffin
Specificity and Use
NPPA / ANP antibody was raised against synthetic peptide corresponding to part of the native molecule conjugated to Bovine Serum Albumin.
Recognizes both the whole human atrial natriuretic peptide and the c terminal fragment (amino acids 4-28). ANP is formed by the cleavage of the holo Natriuretic peptides A by CORIN to release functionally active ANP.
Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.