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Anti-NPC / NPC1 Antibody (Internal) LS-C113011

Ordering

Wt. Vol. Conc. Price
100 µg - 0.5 mg/ml $335

LSBio (Direct) LSBio (Direct)
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Goat Polyclonal to Mouse NPC / NPC1
Mouse
ELISA
Unconjugated

Details

Mouse NPC / NPC1
Goat
Mouse (tested or 100% immunogen sequence identity)
Rat (at least 90% immunogen sequence identity)
Polyclonal
Immunoaffinity purified

Applications

ELISA (1:16000)

Specificity and Use

NPC / NPC1 antibody was raised against synthetic peptide C-TYHTILKTSADYTD from an internal region of mouse NPC1 (NP_032746.2). Percent identity with other species by BLAST analysis: Mouse (100%), Rat (93%), Hamster (86%).
LS-E27388 - Lyophilized - 100 µg - $145.00
Internal
Mouse NPC1.
Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Preliminary experiments gave an approx 36kDa band in lysates of cell lines NIH3T3 and NSO after 1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 142kDa according to NP_032746.2. The 36kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Store at -20°C. Minimize freezing and thawing.
For research use only.

About NPC / NPC1

NM_000271

NPC1 Antibody, NPC Antibody, Niemann-Pick C1 protein Antibody, Niemann-Pick disease, type C1 Antibody

Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE.

Requested From: United States
Date Requested: 8/28/2015

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