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Anti-NPC / NPC1 Antibody (C-Terminus) IHC-plus™ LS-B509

Note: This antibody replaces LS-C2579
Catalog Size Price
LS-B509-50 50 µl (1 mg/ml) Unavailable

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100% Guaranteed
Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse, Hamster, Primate
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation (applications tested for the base form of this product only)
Unconjugated

Details

Human NPC / NPC1
Rabbit
Human, Mouse, Hamster, Primate (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated. Also available conjugated with Biotin, DY650, DY488, DY550.
Affinity purified
Unmodified

Applications

  • IHC - Paraffin (5 - 10 µg/ml)
  • Immunofluorescence (1:250)
  • Western blot (1:1000 - 1:3000)
  • Immunoprecipitation
  • (applications tested for the base form of this product only)

Specificity and Use

NPC / NPC1 antibody was raised against a synthetic peptide made to the C-terminal region of human NPC1
C-Terminus
NPC1 protein.
Immunohistochemistry: LS-B509 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B509 was determined to be 5-10 ug/ml.

Packaging

0.025% sodium azide.
Long term: -70°C; Short term: +4°C
For research use only.

About NPC / NPC1

NM_000271

NPC1 Antibody, NPC Antibody, Niemann-Pick C1 protein Antibody, Niemann-Pick disease, type C1 Antibody

Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE.

Immunohistochemistry

Immunohistochemistry
Anti-NPC1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B509 concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

Requested From: 
Date Requested: 6/25/2017

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