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Anti-NPC / NPC1 Antibody (C-Terminus) IHC-plus™ LS-B509

Note: This antibody replaces LS-C2579


Wt. Vol. Conc. Price
- 50 µl 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Alternate Forms of this Antibody

LS-C142211 Biotin Conjugated
LS-C142212 DY650 Conjugated
LS-C142213 DY488 Conjugated
LS-C142215 DY550 Conjugated

Most Popular NPC / NPC1 Antibodies

Anti-NPC / NPC1 Antibody IHC-plus™ LS-B3437
Mouse Monoclonal (IgG1) to Human NPC / NPC1
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation
Immunohistochemistry Image
Anti-NPC / NPC1 Antibody (C-Terminus, clone EPR5209) IHC-plus™ LS-B6281
Rabbit Monoclonal [clone EPR5209] to Human NPC / NPC1
Human, Mouse, Rat
IHC - Paraffin, ICC, Western blot
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human NPC / NPC1
Human, Mouse, Hamster, Primate
IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation (applications tested for the base form of this product only)


Human NPC / NPC1
Human, Mouse, Hamster, Primate (tested or 100% immunogen sequence identity)
Affinity purified


  • IHC - Paraffin (5 - 10 µg/ml)
  • Immunofluorescence (1:250)
  • Western blot (1:1000 - 1:3000)
  • Immunoprecipitation
  • (applications tested for the base form of this product only)

Specificity and Use

NPC / NPC1 antibody was raised against a synthetic peptide made to the C-terminal region of human NPC1
NPC1 protein.
Immunohistochemistry: LS-B509 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B509 was determined to be 5-10 ug/ml.


0.025% sodium azide.
Long term: -70°C; Short term: +4°C
For research use only.

About NPC / NPC1


NPC1 Antibody, NPC Antibody, Niemann-Pick C1 protein Antibody, Niemann-Pick disease, type C1 Antibody

Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE.


Anti-NPC1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B509 concentration 10 ug/ml. This image was taken for the base form of this product. Alternate forms, such as conjugated, azide-free, or ready-to-use, have not been tested.

Requested From: United States
Date Requested: 10/24/2016

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