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Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.
Gene Name: | NADPH oxidase, EF-hand calcium binding domain 5 |
Synonyms: | NOX5, NADPH oxidase 5, NOX5A, NOX5B |
Target Sequences: | NM_024505 NP_078781.3 Q96PH1 |
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