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Anti-NOTCH4 Antibody (clone HMN4-14) LS-C188665


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $235
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Alternate Forms of this Antibody

LS-C187540 RPE Conjugated

Most Popular NOTCH4 Antibodies

Anti-NOTCH4 Antibody (aa371-420) IHC-plus™ LS-B3498
Rabbit Polyclonal (IgG) to Human NOTCH4
Human, Bovine, Guinea pig, Horse, Pig
IHC - Paraffin, Western blot
Immunohistochemistry Image
Anti-NOTCH4 Antibody (clone HMN4-14, PE) LS-C106197
Hamster Monoclonal [clone HMN4-14] (IgG) to Mouse NOTCH4
Flow Cytometry
PE Conjugated
Flow Cytometry Image
Anti-NOTCH4 Antibody (clone L5C5) IHC-plus™ LS-B7289
Mouse Monoclonal [clone L5C5] (IgG1) to Human NOTCH4
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Hamster Monoclonal [clone HMN4-14] (IgG) to Mouse NOTCH4
Flow Cytometry (applications tested for the base form of this product only)


Mouse NOTCH4
Mouse (tested or 100% immunogen sequence identity)
IgG Monoclonal [HMN4-14]
Protein G purified


  • Flow Cytometry
  • (applications tested for the base form of this product only)

Specificity and Use

NOTCH4 antibody was raised against mouse Notch 4-Fc fusion protein.
Recognizes mouse Notch 4, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta-like protein 1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Notch 4 is expressed by endothelial cells, macrophages, and CD8+ splenic dendritic cells, and Notch 4 signalling may play a crucial role in vasculogenesis and angiogenesis. In mice, a truncated constitutively active form of Notch 4, designated Int3, also exists, as a result of the mouse mammary tumor virus (MMTV).


PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About NOTCH4

Q99466 NM_004557 NP_004548.3

NOTCH4 Antibody, HNotch4 Antibody, Notch (Drosophila) homolog 4 Antibody, Notch homolog 4 (Drosophila) Antibody, Notch homolog 4 Antibody, INT3 Antibody, Notch 4 Antibody

NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions.

Requested From: United States
Date Requested: 10/23/2016

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