NOTCH4

notch 4

NOTCH4 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. This gene may be associated with susceptibility to schizophrenia in a small portion of cases. An alternative splice variant has been described but its biological nature has not been determined.

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Products

Antibodies (52)

ELISA Kits (4)

Proteins (4)

Type

Custom (1)

Over-Expression Lysate (2)

Primary (52)

Recombinant (2)

Sandwich (3)

Target

NOTCH4 (60)

Reactivity

Human (41)

Mouse (16)

Rat (23)

Bovine (6)

Chimpanzee (3)

Gibbon (3)

Guinea pig (3)

Horse (6)

Monkey (2)

Pig (6)

Application

IHC (10)

IHC-P (8)

WB (50)

ELISA (7)

ICC (2)

IF (1)

IP (1)

Peptide-ELISA (4)

Host

rabbit (48)

mouse (1)

goat (2)

rat (1)

Product Group

IHCPlus (2)

Isotype

IgG (20)

IgG1 (1)

IgG2a (1)

Clonality

monoclonal mc (2)

polyclonal pc (50)

Clone

L5C5 (1)

Format

96-Well Strip Plate (4)

APC (2)

APC Conjugated (3)

Biotin Conjugated (6)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (3)

Unconjugated (24)

Epitope

aa1690-1945 (8)

aa1715-2001 (8)

C-Terminus (7)

Internal (4)

aa371-420 (4)

aa1778-2003 (2)

1370-1450 aa, C-terminal (1)

Cleaved-Val1432 (1)

aa1261-1273 (1)

aa1401-1450 (1)

aa1805-1818 (1)

aa1819-1851 (1)

aa5708-6217 (1)

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Publications

No (58)

Yes (2)

Sample Type

Cell Lysates (1)

Plasma (2)

Serum (2)

Tissue Homogenates (2)

Tag

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (2)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

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NOTCH4 Antibody (aa371-420) LS-B3498

(4.1) Rating

(2) Publication(s)

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (aa371-420) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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NOTCH4 Antibody (aa371-420, HRP) LS-C428440

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (aa371-420) (HRP) Antibody

Reactivity:

Guinea pig, Bovine, Pig, Horse, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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NOTCH4 Antibody (aa371-420, Biotin) LS-C428437

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (aa371-420) (Biotin) Antibody

Reactivity:

Guinea pig, Bovine, Pig, Horse, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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NOTCH4 Antibody (aa371-420, FITC) LS-C428438

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (aa371-420) (FITC) Antibody

Reactivity:

Guinea pig, Bovine, Pig, Horse, Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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IHC-plus™ NOTCH4 Antibody (clone L5C5) LS-B7289

(4.0) Rating

Antibody:

NOTCH4 Mouse anti-Human Monoclonal (L5C5) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µl/$565

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NOTCH4 Antibody (C-Terminus) LS-C137135

(4.1) Rating

(2) Publication(s)

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µl/$332

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Human NOTCH4 (Sandwich ELISA) ELISA Kit - LS-F12176

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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NOTCH4 Antibody (1370-1450 aa, C-terminal) LS-C380512

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (1370-1450 aa, C-terminal) Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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NOTCH4 Antibody (aa5708-6217) LS-C91117

Antibody:

NOTCH4 Rabbit anti-Mouse Polyclonal (aa5708-6217) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

200 µg/$820

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NOTCH4 Antibody (aa1261-1273) LS-C154837

Antibody:

NOTCH4 Goat anti-Human Polyclonal (aa1261-1273) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

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Human NOTCH4 (Sandwich ELISA) ELISA Kit - LS-F39100

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$902

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Human NOTCH4 Protein (Recombinant His-T7) (aa1715-2001) - LS-G16109

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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NOTCH4 Antibody LS-C832618

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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NOTCH4 Antibody (aa1778-2003) LS-C37775

Antibody:

NOTCH4 Rat anti-Human Monoclonal (aa1778-2003) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

100 µg/$884

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NOTCH4 Antibody (aa1778-2003) LS-C37776

Antibody:

NOTCH4 Goat anti-Human Polyclonal (aa1778-2003) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

100 µg/$941

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NOTCH4 Antibody (Cleaved-Val1432) LS-C821734

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (Cleaved-Val1432) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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NOTCH4 Antibody LS-C803804

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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NOTCH4 Antibody (aa1401-1450) LS-C199338

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (aa1401-1450) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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NOTCH4 Antibody (aa1819-1851) LS-C356711

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (aa1819-1851) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

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NOTCH4 Antibody LS-C768594

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

NOTCH4 Antibody (Internal) LS-C109636

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

NOTCH4 Antibody (Internal, HRP) LS-C427043

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (Internal) (HRP) Antibody

Reactivity:

Pig, Human

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

NOTCH4 Antibody (Internal, Biotin) LS-C427294

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody

Reactivity:

Pig, Human

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

NOTCH4 Antibody (Internal, FITC) LS-C427041

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (Internal) (FITC) Antibody

Reactivity:

Pig, Human

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

NOTCH4 Antibody (C-Terminus) LS-C116886

Antibody:

NOTCH4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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