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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NOTCH2 Antibody (N‑Terminus) IHC‑plus™ LS‑B719
Note: This antibody replaces LS-C19117, LS-C73701
NOTCH2 antibody LS-B719 is an unconjugated rabbit polyclonal antibody to human NOTCH2. Validated for ELISA and IHC. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
Catalog
Size
Price
LS-B719-50
50 µl
Unavailable

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Product Description

NOTCH2 antibody LS-B719 is an unconjugated rabbit polyclonal antibody to human NOTCH2. Validated for ELISA and IHC. Tested on 20 paraffin-embedded human tissues. Cited in 1 publication.
About NOTCH2
NOTCH2 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. Q04721 NM_024408 NP_077719.2

NOTCH2 Antibody, AGS2 Antibody, HN2 Antibody, Notch (Drosophila) homolog 2 Antibody, Notch homolog 2 (Drosophila) Antibody, Notch 2 Antibody, Notch homolog 2 Antibody, HJCYS Antibody


Specifications

Target
Human NOTCH2
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Sterile filtered
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:500)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
NOTCH2 antibody was raised against synthetic peptide from human NOTCH2.
Epitope
N-Terminus
Specificity
Amino acid residues of human Notch 2 located near the N-terminal sequence of the cleaved N intracellular domain (NICD).
Usage
Immunohistochemistry: LS-B719 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B719 was determined to be 1:500.
Presentation
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

Publications (1)

1
Notch signaling pathway in cumulus cells can be a novel marker to identify poor and normal responder IVF patients. Tanriverdi G, Denir S, Ayla S, Bilir A, Oktar H, Cepni I, Irez T. Journal of assisted reproduction and genetics. 2013 Oct;30:1319-26. [Full Text Article] [PubMed:23922013] [PMC:PMC3824856]

Customer Reviews (0)


Images


Immunohistochemistry

Anti-NOTCH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B719 dilution 1:500.
Anti-NOTCH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B719 dilution 1:500.

Immunohistochemistry

Anti-NOTCH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B719 dilution 1:500.
Anti-NOTCH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B719 dilution 1:500.

Immunohistochemistry

Anti-NOTCH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B719 dilution 1:500.
Anti-NOTCH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B719 dilution 1:500.

Immunohistochemistry

Anti-NOTCH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B719 dilution 1:500.
Anti-NOTCH2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B719 dilution 1:500.


Requested From: 
Date Requested: 6/24/2018

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