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Anti-NOTCH2 Antibody (clone HMN2-35) LS-C188663


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $235
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Alternate Forms of this Antibody

LS-C187539 RPE Conjugated

Most Popular NOTCH2 Antibodies

Anti-NOTCH2 Antibody (aa2396-2409) IHC-plus™ LS-B399
Rabbit Polyclonal to Human NOTCH2
Human, Dog
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Immunohistochemistry Image
Anti-NOTCH2 Antibody (N-Terminus) IHC-plus™ LS-B719
Rabbit Polyclonal to Human NOTCH2
IHC - Paraffin, ELISA
Immunohistochemistry Image
Anti-NOTCH2 Antibody LS-C150303
Goat Polyclonal (IgG) to Rat NOTCH2
IHC, Western blot, Flow Cytometry, ELISA, Blocking

100% Guaranteed 100% Guaranteed
Hamster Monoclonal [clone HMN2-35] (IgG) to Mouse NOTCH2
Mouse, Rat
Flow Cytometry (applications tested for the base form of this product only)


Mouse NOTCH2
Mouse, Rat (tested or 100% immunogen sequence identity)
IgG Monoclonal [HMN2-35]
Protein G purified


  • Flow Cytometry
  • (applications tested for the base form of this product only)

Specificity and Use

NOTCH2 antibody was raised against mouse Notch 2-Fc fusion protein.
Recognizes Notch 2, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Signalling through Notch 2 has been implicated in the development of marginal zone B cells (MZB), the sensitization of endothelial cells to apoptosis, and the regulation of the expression of CD23 in B-cell lymphocytic leukaemia (B-CLL). Studies have also shown a correlation between a decrease in Notch 2 expression and an increase in grade of human breast cancer. Clone HMN2-35 has been shown to cross-react with rat mast cell line RBL-2H3 and Y3 myeloma cells, in flow cytometry.


PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About NOTCH2

Q04721 NM_024408 NP_077719.2

NOTCH2 Antibody, AGS2 Antibody, HN2 Antibody, Notch (Drosophila) homolog 2 Antibody, Notch homolog 2 (Drosophila) Antibody, Notch 2 Antibody, Notch homolog 2 Antibody, HJCYS Antibody

NOTCH2 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions.

Requested From: United States
Date Requested: 10/20/2016

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