NOTCH1

notch 1

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

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Antibodies (102)

ELISA Kits (15)

Proteins (6)

Type

Custom (3)

Development Kit (2)

Over-Expression Lysate (2)

Primary (102)

Recombinant (4)

Sandwich (10)

Target

NOTCH1 (123)

Reactivity

Human (89)

Mouse (59)

Rat (32)

Bovine (3)

Dog (2)

Guinea pig (1)

Hamster (2)

Horse (2)

Monkey (1)

Pufferfish (1)

Sheep (1)

Zebrafish (1)

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Application

IHC (49)

IHC-Fr (6)

IHC-P (19)

WB (69)

Flo (18)

DB (1)

ELISA (29)

ICC (24)

IF (8)

IP (10)

Peptide-ELISA (6)

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rabbit (58)

mouse (39)

goat (2)

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DevKit DuoPlus (2)

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PathPlus Neuro (1)

Isotype

IgG (39)

IgG,l (1)

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IgG1,k (2)

IgG1,l (1)

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Clonality

monoclonal mc (38)

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recombinant monoclonal rmc (2)

Clone

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E6 (2)

mN1A (7)

OTI2E7 (2)

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S253-32 (12)

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12 x 8-Well Microstrips (1)

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Antibody Pair and Standard (2)

AP Conjugated (1)

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Epitope

aa20-216 (11)

C-Terminus (10)

aa19-526 (5)

Internal (4)

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Notch 1 (2)

aa2280-2556 (2)

aa2300-2556 (2)

aa2428-2556 (2)

aa2505-2555 (2)

1710-1790 aa, Internal (1)

Amino Acids 171-182 (1)

Cleaved Val1744 (1)

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Val1754 (1)

aa1735-1784 (1)

aa1754-1766 (1)

aa1754-2556 (1)

aa1755-1767 (1)

aa2272-2488 (1)

aa2400-2450 (1)

aa2403-2437 (1)

aa2428-2462 (1)

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Publications

No (120)

Yes (3)

Sample Type

Cell Culture Supernatants (5)

Cell Lysates (6)

Plasma (11)

Serum (11)

Tissue Homogenates (8)

Tag

GST, N-terminus (1)

His,C-terminus (2)

Human IgG1 Fc (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Mouse (3)

Source

293T Cells (1)

CHO Cells (1)

HEK 293 Cells (1)

Insect Cells (1)

Mammalian Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (3)

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PathPlus™ NOTCH1 Antibody (aa2480-2510) LS-B398

Neuroscience

(5.0) Rating

(1) Publication(s)

Antibody:

NOTCH1 Rabbit anti-Human Polyclonal (aa2480-2510) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$515

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NOTCH1 Antibody (clone OTI3E12) LS-C114369

Antibody:

NOTCH1 Mouse anti-Human Monoclonal (OTI3E12) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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NOTCH1 Antibody (aa2300-2556, clone OTI3E12, Carrier-free) LS-C784102

Antibody:

NOTCH1 Mouse anti-Human Monoclonal (aa2300-2556) (Carrier-free) (OTI3E12) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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NOTCH1 Antibody (Val1754) LS-C178239

Antibody:

NOTCH1 Rabbit anti-Human Polyclonal (Val1754) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$328; 100 µl/$419

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NOTCH1 Antibody (aa2487-2501) LS-C16928

(4.1) Rating

(2) Publication(s)

Antibody:

NOTCH1 Rabbit anti-Human Polyclonal (aa2487-2501) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µl/$634

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NOTCH1 Antibody (N-Terminus) LS-C19109

(4.2) Rating

(3) Publication(s)

Antibody:

NOTCH1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$567

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Human NOTCH1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90569

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

272.58 kDa

Price:

20 µg/$215

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Mouse NOTCH1 (Sandwich ELISA) ELISA Kit - LS-F14664

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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NOTCH1 Antibody (aa2428-2556) LS-C73692

Antibody:

NOTCH1 Mouse anti-Human Monoclonal (aa2428-2556) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

100 µg/$884

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IHC-plus™ NOTCH1 Antibody (aa2272-2488) LS-B8716

(4.0) Rating

Antibody:

NOTCH1 Rabbit anti-Rat Polyclonal (aa2272-2488) Antibody

Reactivity:

Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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NOTCH1 Antibody (clone mN1A) LS-C359244

Antibody:

NOTCH1 Mouse anti-Mouse Monoclonal (mN1A) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, ICC, IF, IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

0.1 ml/$386

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NOTCH1 Antibody (aa1755-1767) LS-C47387

Antibody:

NOTCH1 Rabbit anti-Human Polyclonal (aa1755-1767) Antibody

Reactivity:

Zebrafish, Pufferfish, Rat, Mouse, Dog, Bovine, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$386

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NOTCH1 Antibody (aa2487-2506) LS-C388980

Antibody:

NOTCH1 Rabbit anti-Human Polyclonal (aa2487-2506) Antibody

Reactivity:

Mouse, Guinea pig, Sheep, Bovine, Rat, Hamster, Horse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$575

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NOTCH1 Antibody (clone mN1A) LS-C44817

Antibody:

NOTCH1 Mouse anti-Mouse Monoclonal (mN1A) Antibody

Reactivity:

Mouse

Applications:

Flo, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

0.1 mg/$395

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NOTCH1 Antibody (clone mN1A, FITC) LS-C188303

Antibody:

NOTCH1 Mouse anti-Mouse Monoclonal (FITC) (mN1A) Antibody

Reactivity:

Mouse

Applications:

Flo, IHC, IHC-Fr

Format:

FITC Conjugated

Price:

0.1 mg/$444

• Unconjugated
• FITC

• Unconjugated
• FITC

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IHC-plus™ NOTCH1 Antibody (Amino Acids 171-182) LS-B16439

(4.0) Rating

Antibody:

NOTCH1 Goat anti-Human Polyclonal (Amino Acids 171-182) Antibody

Reactivity:

Human

Applications:

IF, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$460

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NOTCH1 Antibody (aa19-526) LS-C126048

Antibody:

NOTCH1 Sheep anti-Mouse Polyclonal (aa19-526) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$930

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NOTCH1 Antibody (clone 4G1) LS-C197793

Antibody:

NOTCH1 Mouse anti-Human Monoclonal (4G1) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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NOTCH1 Antibody (aa19-526) LS-C126049

Antibody:

NOTCH1 Mouse anti-Human Monoclonal (aa19-526) Antibody

Reactivity:

Human

Applications:

Flo

Format:

Unconjugated

Price:

100 µg/$896

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NOTCH1 Antibody (Internal) LS-C356230

Antibody:

NOTCH1 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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NOTCH1 Antibody (aa19-526, Biotin) LS-C131092

Antibody:

NOTCH1 Mouse anti-Human Monoclonal (aa19-526) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

250 µg/$978

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NOTCH1 Antibody (aa19-526, APC) LS-C126050

Antibody:

NOTCH1 Mouse anti-Human Monoclonal (aa19-526) (APC) Antibody

Reactivity:

Human

Applications:

Flo

Format:

APC Conjugated

Price:

100 Tests/$866

• Biotin
• APC

• Biotin
• APC

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NOTCH1 Antibody LS-C124291

Antibody:

NOTCH1 Mouse anti-Mouse Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

Flo, IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$611

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NOTCH1 Antibody (clone mN1A) LS-C204312

Antibody:

NOTCH1 Mouse anti-Mouse Monoclonal (mN1A) Antibody

Reactivity:

Mouse, Human

Applications:

Flo, ICC, IHC-Fr, IP, WB

Format:

Unconjugated

Price:

0.1 mg/$302

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NOTCH1 Antibody (C-Terminus, HRP) LS-C438333

Antibody:

NOTCH1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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