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Anti-NOTCH1 Antibody (clone mN1A, FITC) LS-C188303


Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $355

LSBio (Direct) LSBio (Direct)

NOTCH1 Antibody LS-C188303 Images

[click image for a larger image and more details]
Flow Cytometry
Flow cytometry of mouse thymocytes with Mouse anti-Mouse NOTCH-1:FITC

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Mouse Monoclonal [clone mN1A] (IgG1) to Mouse NOTCH1
Mouse, Human
Flow Cytometry
FITC Conjugated


Mouse NOTCH1
Mouse, Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [mN1A]
Fluorescein (FITC)
Protein G purified


Flow Cytometry (1:1 - 1:10)

Specificity and Use

NOTCH1 antibody was raised against synthetic peptide corresponding to cdc10-NCR region within mouse Notch1.
Specifically recognizes Notch 1, one of the four major transmembrane receptors (Notch 1-4) of the Notch signalling pathway, which is activated through binding to DSL domain-containing membrane-bound specific ligands. The Notch signalling pathway is an evolutionarily conserved pathway in multi-cellular organisms, which is vital for cell-cell communication, important during fundamental developmental and physiological processes, including regulation of cell fate decisions during neuronal, cardiac and endocrine development, stem cell haematopoiesis, thymic T-cell development, and both tumor progression and suppression. Ligation of Notch receptors by their specific ligands, Jagged1 (CD339), Jagged2, Delta like-1 (DLL1), DLL3 and DLL4, on physically adjacent signal receiving cells, induces proteolysis of the receptors by ADAM-family metalloproteases and gamma-secretase complex, within the transmembrane domain, releasing the Notch intracellular domain (NICD) to translocate to the nucleus. Subsequent signal transduction then occurs through either the CSL-NICD-Mastermind complex cascade (canonical pathway), or NF-kappaB-NICD and CSL-NICD-Deltex complex signalling cascades (non-canonical pathway). The canonical pathway inhibits the differentiation of stem cells or progenitor cells, whilst the non-canonical pathway promotes differentiation. Notch 1 is expressed in a range of cells including hematopoietic cells in mouse fetal liver, adult thymus and bone marrow. Notch 1 signalling p ...


PBS, 0.09% sodium azide, 1% BSA
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About NOTCH1

P46531 NM_017617 NP_060087.3

NOTCH1 Antibody, Notch 1 Antibody, TAN1 Antibody

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Flow Cytometry

Flow Cytometry
Flow cytometry of mouse thymocytes with Mouse anti-Mouse NOTCH-1:FITC

Requested From: United States
Date Requested: 10/4/2015

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