Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Guinea pig (tested or 100% immunogen sequence identity)
Specificity and Use
NOS3 / eNOS antibody was raised against peptide corresponding to amino acids 106-118 of human eNOS/NOS III (Ser116) (PRKLQGRPpSPGPP-C) Percent identity by BLAST analysis: Human, Chimpanzee, Gibbon, Monkey, Guinea pig (100%).
ENOS/NOS III phosphorylated on serine 116
0.2 M Tris-glycine, pH 7.4, 0.15 M sodium chloride, 0.1 mM EDTA, 0.05% sodium azide, 30% glycerol
NOS3 Antibody, Constitutive NOS Antibody, CNOS Antibody, Endothelial NOS Antibody, ECNOS Antibody, NOS type III Antibody, NOSIII Antibody, EC-NOS Antibody, ENOS Antibody, Nitric oxide synthase 3 Antibody
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.