NOG / Noggin

noggin

The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.

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Products

Antibodies (114)

Proteins (31)

ELISA Kits (13)

Type

Custom (3)

Development Kit (3)

Native (1)

Over-Expression Lysate (2)

Primary (114)

Recombinant (28)

Sandwich (7)

Target

NOG / Noggin (158)

Reactivity

Human (71)

Mouse (30)

Rat (52)

Bat (3)

Bovine (3)

Chicken (9)

Chimpanzee (3)

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IHC (16)

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WB (105)

ELISA (19)

ICC (1)

IF (6)

IP (1)

Peptide-ELISA (1)

Host

rabbit (81)

mouse (33)

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DevKit DuoPlus (3)

Isotype

IgG (27)

IgG2b (6)

IgG2b,k (16)

IgG3 (1)

Clonality

monoclonal mc (33)

polyclonal pc (81)

Clone

OTI1C1 (2)

OTI1H8 (2)

OTI4C12 (2)

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96-Well Microplate (1)

96-Well Strip Plate (9)

Animal-free (1)

Antibody Pair and Standard (3)

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Carrier-free (3)

Cy3 Conjugated (9)

Cy7 Conjugated (9)

FITC Conjugated (14)

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PE Conjugated (10)

Unconjugated (36)

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Epitope

aa28-232 (33)

aa28-144 (16)

aa27-223 (8)

aa28-240 (8)

aa84-111 (7)

aa71-120 (4)

Publications

No (156)

Yes (2)

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Cell Culture Supernatants (6)

Cell Lysates (5)

Plasma (9)

Serum (9)

Tissue Homogenates (7)

Tag

6His, C-terminus (1)

6His, N-terminus (1)

Fc (1)

Fc, C-terminus (1)

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His (5)

His,C-terminus (2)

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His-GST, N-terminus (2)

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Chicken (1)

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Biologically active (11)

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Animal-free (1)

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Human NOG / Noggin (Sandwich ELISA) ELISA Kit - LS-F39610

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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Mouse NOG / Noggin (Sandwich ELISA) ELISA Kit - LS-F54694

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.25 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$958

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Human NOG / Noggin (Sandwich ELISA) ELISA Kit - LS-F24239

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

125 - 8000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Mouse/Human/Rat NOG / Noggin (Sandwich ELISA) ELISA Kit - LS-F5920

(4.0) Rating

(1) Publication(s)

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse, Human, Rat

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$854

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Human NOG / Noggin (Sandwich ELISA) ELISA Kit - LS-F12164

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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NOG / Noggin Antibody (clone OTI1H8) LS-C114325

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal (OTI1H8) Antibody

Reactivity:

Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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NOG / Noggin Antibody (aa28-232, clone OTI1H8, Carrier-free) LS-C784062

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal (aa28-232) (Carrier-free) (OTI1H8) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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NOG / Noggin Antibody (aa84-111) LS-C323390

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal (aa84-111) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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NOG / Noggin Antibody (aa84-111, Azide-free, HRP) LS-C248935

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal (aa84-111) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• HRP, Azide-free

• Unconjugated
• HRP, Azide-free

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NOG / Noggin Antibody (clone OTI4C12) LS-C114324

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal (OTI4C12) Antibody

Reactivity:

Dog, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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NOG / Noggin Antibody (aa28-232, clone OTI4C12, Carrier-free) LS-C784060

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal (aa28-232) (Carrier-free) (OTI4C12) Antibody

Reactivity:

Dog, Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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NOG / Noggin Antibody (aa84-111) LS-C158405

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal (aa84-111) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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Rat NOG / Noggin Protein (Recombinant His-GST, N-terminus) (Gly1-Trp117) - LS-G14800

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

40.1 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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NOG / Noggin Antibody (clone OTI1C1) LS-C114385

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal (OTI1C1) Antibody

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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NOG / Noggin Antibody (aa28-232, clone OTI1C1, Carrier-free) LS-C784113

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal (aa28-232) (Carrier-free) (OTI1C1) Antibody

Reactivity:

Human

Applications:

IF, IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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NOG / Noggin Antibody LS-C660343

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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NOG / Noggin Antibody LS-C678834

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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NOG / Noggin Antibody LS-C743315

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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NOG / Noggin Antibody LS-C393627

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µl/$391

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NOG / Noggin Antibody LS-C813914

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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NOG / Noggin Antibody (aa71-120) LS-C116798

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal (aa71-120) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$424

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NOG / Noggin Antibody (aa28-232) LS-C126043

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal (aa28-232) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$680

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NOG / Noggin Antibody LS-C830009

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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NOG / Noggin Antibody LS-C831229

Antibody:

NOG / Noggin Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

NOG / Noggin Antibody LS-C813057

Antibody:

NOG / Noggin Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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