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Anti-NOD2 / CARD15 Antibody (aa582-600) LS-C148280

Ordering

Wt. Vol. Conc. Price
- 50 µl - $335
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular NOD2 / CARD15 Antibodies

Anti-NOD2 / CARD15 Antibody (C-Terminus) IHC-plus™ LS-B2721
Rabbit Polyclonal to Human NOD2 / CARD15
Human
IHC - Paraffin, ICC, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-NOD2 / CARD15 Antibody (clone 26mNOD2) IHC-plus™ LS-B5951
Rat Monoclonal [clone 26mNOD2] (IgG1,k) to Mouse NOD2 / CARD15
Mouse
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-NOD2 / CARD15 Antibody (aa125-140) LS-C148178
Rabbit Polyclonal to Human NOD2 / CARD15
Human
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal to Human NOD2 / CARD15
Human
IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation
Unconjugated

Details

Human NOD2 / CARD15
Rabbit
Human (tested or 100% immunogen sequence identity)
Monkey (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Antiserum
Unmodified

Applications

  • IHC - Paraffin (1:1000 - 1:5000)
  • IHC - Frozen
  • Western blot (1:1000 - 1:2000)
  • Immunoprecipitation (1:50 - 1:200)

Specificity and Use

NOD2 / CARD15 antibody was raised against a synthetic peptide corresponding to amino acids 582-600 (LGFLVRAKGVVPGSTAPLE) of human NOD2/CARD15. NOD2 is a 1040 amino acid protein. The immunogen sequence is 100% conserved in certain NOD2 isoforms and mutations. Percent identity by BLAST analysis: Human, Chimpanzee, Gibbon (100%); Monkey (95%); Gorilla, Orangutan, Sheep, Zebu, Bovine, Rabbit (89%); Tamarin, Rat, Elephant, Pig (84%); Mouse (79%).
aa582-600
Human NOD2.

Packaging

Antiserum, 0.05% sodium azide
Store at -20°C. Aliquot to avoid freeze/thaw cycles.
For research use only.

About NOD2 / CARD15

Q9HC29 NM_022162 NP_071445.1

NOD2 Antibody, BLAU Antibody, CARD15 Antibody, ACUG Antibody, NOD-like receptor C2 Antibody, NOD2B Antibody, NLRC2 Antibody, IBD1 Antibody, CLR16.3 Antibody, PSORAS1 Antibody

Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response.

Immunohistochemistry

Immunohistochemistry
Formalin-fixed, paraffin-embedded normal human colon stained for NOD2 expression using LS-C148280 at 1:2000. A, tissue core from a colon tissue microarray. A1, high magnification of A. Hematoxylin-Eosin counterstain.

Western blot

Western blot
Western blot of NOD2 using LS-C148280 at 1:2000.30 ug total protein was loaded per lane. Samples from human tumor cell lines: PPC-1 (prostate carcinoma), NCI-H226and NCI-H332M (lung carcinoma), SF-268 (glioblastoma), UO-31 and A498 (renal/kidney carcinoma), SK-MEL-5 and SK-MEL-28 (melanoma), and MCF-7 (breast carcinoma). Lymphoma is from a cell line generated from a tumor growing in nude mice following injection of primary human lymphoma cells.

Requested From: United States
Date Requested: 12/7/2016

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