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Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2.
Gene Name: | nitrilase 1 |
Synonyms: | NIT1, Nitrilase 1, Nitrilase homolog 1 |
Target Sequences: | NM_005600 NP_005591.1 Q86X76 |
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