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NIP3 / BNIP3
BCL2/adenovirus E1B 19kDa interacting protein 3
Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway.
| Gene Name: | BCL2/adenovirus E1B 19kDa interacting protein 3 |
| Synonyms: | BNIP3, NIP3 |
| Target Sequences: | NM_004052 NP_004043.3 Q12983 |
Publications (1)
1
Chronic autophagy is a cellular adaptation to tumor acidic pH microenvironments. Wojtkowiak JW, Rothberg JM, Kumar V, Schramm KJ, Haller E, Proemsey JB, Lloyd MC, Sloane BF, Gillies RJ. Cancer research. 2012 72:3938-47.
[PubMed:22719070]
Related Antibodies: LS-C98865.
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NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa152-187) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
E. coli
10His, N-terminus
23.8 kDa
100 µg/$1,801; 20 µg/$1,247
NIP3 / BNIP3 Mouse anti-Human Monoclonal (aa112-124) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$715
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$399
293T Cells
Myc-DDK (Flag)
21.4 kDa
20 µg/$150
NIP3 / BNIP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NIP3 / BNIP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IHC, IHC-P
Unconjugated
0.1 ml/$386
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (DY550) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY550 Conjugated
0.1 ml/$416
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (DY488) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY488 Conjugated
0.1 ml/$416
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (DY650) Antibody
Mouse, Human
ICC, IHC, IHC-P
DY650 Conjugated
0.1 ml/$416
NIP3 / BNIP3 Mouse anti-Human Monoclonal (6A5F7) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa47-96) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa152-187) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa152-187) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated
200 µl/$952
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa152-187) (Biotin) Antibody
Mouse, Human
ELISA, IF, IHC, WB
Biotin Conjugated
200 µl/$952
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa152-187) (FITC) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa152-187) (APC) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa152-187) (PE) Antibody
Mouse, Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
E. coli
His, N-Terminal
19 kDa
10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa122-139) Antibody
Xenopus, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µl/$386
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (aa1-164) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
NIP3 / BNIP3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
100 µg/$442
NIP3 / BNIP3 Rabbit anti-Human Polyclonal Antibody
Xenopus, Chicken, Mouse, Rat, Human
IHC, IP, WB
Unconjugated
50 µl/$393
NIP3 / BNIP3 Mouse anti-Human Monoclonal (4E11F4) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
NIP3 / BNIP3 Rabbit anti-Human Polyclonal (Glu96) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
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