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NF-L / NEFL
neurofilament, light polypeptide
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
| Gene Name: | neurofilament, light polypeptide |
| Synonyms: | NEFL, 68 kDa neurofilament protein, CMT1F, CMT2E, NF68, NF-L, NFL, Neurofilament subunit NF-L, PPP1R110, Neurofilament light polypeptide, CMTDIG |
| Target Sequences: | NM_006158 NP_006149.2 P07196 |
Publications (5)
1
Neuron-glia interactions underlie ALS-like axonal cytoskeletal pathology. King AE, Dickson TC, Blizzard CA, Woodhouse A, Foster SS, Chung RS, Vickers JC. Neurobiology of aging. 2011 32:459-69. (ICC, IHC; Mouse)
[PubMed:19427060]
2
NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons. Yokoyama K, Tezuka T, Kotani M, Nakazawa T, Hoshina N, Shimoda Y, Kakuta S, Sudo K, Watanabe K, Iwakura Y, Yamamoto T. The EMBO journal. 2011 30:4739-54.
[PubMed:21946561]
[PMC:PMC3243607]
3
Microbiome-Derived Lipopolysaccharide (LPS) Selectively Inhibits Neurofilament Light Chain (NF-L) Gene Expression in Human Neuronal-Glial (HNG) Cells in Primary Culture. Lukiw WJ, Cong L, Jaber V, Zhao Y. Frontiers in neuroscience. 2018 December;12:896. [Full Text Article]
[PubMed:30568571]
[PMC:PMC6289986]
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(95)
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(61)
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(1)
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(14)
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(2)
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(1)
aa330-343
(1)
aa485-530
(1)
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(94)
Yes
(1)
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(8)
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(5)
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(18)
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(18)
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(10)
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(1)
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(1)
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(6)
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(2)
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(1)
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(4)
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(1)
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(3)
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Low endotoxin level
(1)
NF-L / NEFL Mouse anti-Human Monoclonal (OTI3G2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
Competitive EIA
96-Well Strip Plate
Mouse
4.94 - 400 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$923
Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
Sandwich
96-Well Strip Plate
Rat
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Pig
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Microplate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Yeast
6His, N-terminus
63.38 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Sandwich CLIA
12 x 8-Well Microstrips
Human
12.5 - 800 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
E. coli
542 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
59.73 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$854
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Competitive EIA
96-Well Strip Plate
Human
123.5 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$798
NF-L / NEFL Mouse anti-Human Monoclonal (DA2) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
200 µg/$890
NF-L / NEFL Chicken anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
NF-L / NEFL Rabbit anti-Human Polyclonal (aa128-271) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Competitive EIA
96-Well Strip Plate
Rat
123.5 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$856
Sandwich
96-Well Strip Plate
Porcine
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$863
E. coli
His
12.6 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
NF-L / NEFL Mouse anti-Pig Monoclonal (DA2) Antibody
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
100 µl/$376
Cancer
NF-L / NEFL Mouse anti-Human Monoclonal (2F11) Antibody
Opossum, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.1 mg/$485
NF-L / NEFL Mouse anti-Human Monoclonal (2G10) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
100 µl/$459
NF-L / NEFL Mouse anti-Pig Monoclonal (DA2) Antibody
Avian, Pig, Mammal, Mouse, Rat, Human
IF, IHC, IHC-Fx, IHC-P, WB
Unconjugated
0.05 ml/$386
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