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Neurofibromin / NF1
neurofibromin 1
Neurofibromin / NF1 appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
| Gene Name: | neurofibromin 1 |
| Synonyms: | NF1, VRNF, Neurofibromin 1, NFNS, WSS, Neurofibromin |
| Target Sequences: | NM_000267 NP_000258.1 P21359 |
Publications (5)
1
Congenital (infantile) pseudarthrosis of the fibula associated with osteofibrous dysplasia. Hisaoka M, Hashimoto H, Ohguri T, Aoki T, Okamoto S, Tanaka H, Okimoto N, Nakamura T, Ishida T. Skeletal radiology. 2004 33:545-9.
[PubMed:15258702]
2
NF1 gene expression in mouse fracture healing and in experimental rat pseudarthrosis. Kuorilehto T, Ekholm E, Nissinen M, Hietaniemi K, Hiltunen A, Paavolainen P, Penttinen R, Peltonen J. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2006 54:363-70.
[PubMed:16314442]
3
S100B and neurofibromin immunostaining and X-inactivation patterns of laser-microdissected cells indicate a multicellular origin of some NF1-associated neurofibromas. Tucker T, Riccardi VM, Brown C, Fee J, Sutcliffe M, Vielkind J, Wechsler J, Wolkenstein P, Friedman JM. Journal of neuroscience research. 2011 89:1451-60.
[PubMed:21674567]
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(32)
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(1)
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (aa2760-C-term) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
Neurofibromin / NF1 Mouse anti-Human Monoclonal (aa27-41) (McNFn27) Antibody
Mouse, Guinea pig, Rat, Human
ELISA, IHC, IHC-P, IP
Unconjugated
0.2 ml/$460
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (aa1551-1600) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P
Unconjugated
50 µl/$460
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (aa27-41) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Pig, Bat, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.5 ml/$460
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (aa1526-1575) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Rat, Pig, Mouse, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
![Neurofibromin / NF1 Antibody - Specificity of Neurofibromin, using Neurofibromin Antibody [McNFn27a], in Schwann cells from embryonic knockout mice, adult human nerves and neonatal rat nerves. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/neurofibromin-nf1-antibody-aa27-41-clone-mcnfn27a-ls-c2721/3186_5013998.jpg)
Neurofibromin / NF1 Mouse anti-Human Monoclonal (aa27-41) (McNFn27a) Antibody
Mouse, Guinea pig, Rat, Human
ELISA, IP, WB
Unconjugated
0.2 ml/$386
![Neurofibromin / NF1 Antibody - Specificity of Neurofibromin, using Neurofibromin Antibody [McNFn27a], in Schwann cells from embryonic knockout mice, adult human nerves and neonatal rat nerves. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/neurofibromin-nf1-antibody-n-terminus-clone-mcnfn27a-biotin-ls-c142055/3186_5013998.jpg)
Neurofibromin / NF1 Mouse anti-Human Monoclonal (N-Terminus) (Biotin) (McNFn27a) Antibody
Mouse, Guinea pig, Rat, Human
ELISA, IP, WB
Biotin Conjugated
0.2 ml/$416
![Neurofibromin / NF1 Antibody - Specificity of Neurofibromin, using Neurofibromin Antibody [McNFn27a], in Schwann cells from embryonic knockout mice, adult human nerves and neonatal rat nerves. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/neurofibromin-nf1-antibody-n-terminus-clone-mcnfn27a-dy650-ls-c142056/3186_5013998.jpg)
Neurofibromin / NF1 Mouse anti-Human Monoclonal (N-Terminus) (DY650) (McNFn27a) Antibody
Mouse, Guinea pig, Rat, Human
ELISA, IP, WB
DY650 Conjugated
0.2 ml/$416
![Neurofibromin / NF1 Antibody - Specificity of Neurofibromin, using Neurofibromin Antibody [McNFn27a], in Schwann cells from embryonic knockout mice, adult human nerves and neonatal rat nerves. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/neurofibromin-nf1-antibody-n-terminus-clone-mcnfn27a-dy550-ls-c142059/3186_5013998.jpg)
Neurofibromin / NF1 Mouse anti-Human Monoclonal (N-Terminus) (DY550) (McNFn27a) Antibody
Mouse, Guinea pig, Rat, Human
ELISA, IP, WB
DY550 Conjugated
0.2 ml/$416
![Neurofibromin / NF1 Antibody - Specificity of Neurofibromin, using Neurofibromin Antibody [McNFn27a], in Schwann cells from embryonic knockout mice, adult human nerves and neonatal rat nerves. This image was taken for the unconjugated form of this product. Other forms have not been tested.](https://lsbio-7d62.kxcdn.com/image2/neurofibromin-nf1-antibody-n-terminus-clone-mcnfn27a-dy488-ls-c142057/3186_5013998.jpg)
Neurofibromin / NF1 Mouse anti-Human Monoclonal (N-Terminus) (DY488) (McNFn27a) Antibody
Mouse, Guinea pig, Rat, Human
ELISA, IP, WB
DY488 Conjugated
0.2 ml/$416
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (1520-1600 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Neurofibromin / NF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
Neurofibromin / NF1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
Neurofibromin / NF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Neurofibromin / NF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Neurofibromin / NF1 Mouse anti-Human Monoclonal (2D1) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
Neurofibromin / NF1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$394
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
Neurofibromin / NF1 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
Sandwich
96-Well Microplate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$595
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