Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Monkey, Horse (tested or 100% immunogen sequence identity)
Bovine, Pig, Rabbit (at least 90% immunogen sequence identity)
IHC - Paraffin (2 µg/ml)
Specificity and Use
NEP / DDR1 antibody was raised against synthetic 16 amino acid peptide from internal region of human DDR1. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Marmoset, Elephant, Horse (100%); Bovine, Rabbit, Pig (94%); Monkey, Panda (88%); Dog, Bat, Opossum, Platypus (81%).
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases.