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NEP / DDR1
discoidin domain receptor tyrosine kinase 1
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
| Gene Name: | discoidin domain receptor tyrosine kinase 1 |
| Family/Subfamily: | Protein Kinase , DDR/TKT |
| Synonyms: | DDR1, Cell adhesion kinase, CD167, CD167a antigen, EDDR1, ENTRK4, Mammary carcinoma kinase 10, MCK10, NEP, PTK3, PTK3A, RTK6, Tyrosine-protein kinase CAK, CAK, DDR, Discoidin domain receptor 1, HGK2, MCK-10, NTRK4, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, TRKE, Tyrosine kinase DDR |
| Target Sequences: | NM_013994 NP_054700.2 Q08345 |
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Fast Shipping
NEP / DDR1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
NEP / DDR1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
NEP / DDR1 Rabbit anti-Human Polyclonal (Internal) Antibody
Pig, Human
IHC, IHC-P
Unconjugated
50 µg/$440
NEP / DDR1 Mouse anti-Human Monoclonal (2G4E12) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
NEP / DDR1 Rabbit anti-Human Monoclonal (11C1024) Antibody
Mouse, Rat, Human, Monkey
ICC, IHC, IP, WB
Unconjugated
100 µl/$625
NEP / DDR1 Rabbit anti-Human Polyclonal (aa299-330) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NEP / DDR1 Rabbit anti-Human Polyclonal (aa17-47) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NEP / DDR1 Rabbit anti-Human Polyclonal (pTyr792) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NEP / DDR1 Rabbit anti-Human Polyclonal (450-530 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NEP / DDR1 Mouse anti-Human Monoclonal (1464CT339.1.54) Antibody
Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
NEP / DDR1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
NEP / DDR1 Rabbit anti-Human Polyclonal (260-340 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NEP / DDR1 Rabbit anti-Human Monoclonal (Preservative Free) (205) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
NEP / DDR1 Mouse anti-Mouse Recombinant Monoclonal (3E3) Antibody
Mouse, Human
Block, ELISA, WB
Unconjugated
0.2 mg/$540
NEP / DDR1 Rabbit anti-Human Polyclonal (aa276-325) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NEP / DDR1 Rabbit anti-Human Monoclonal (Preservative Free) (017) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
45.4 kDa
100 µg/$721
NEP / DDR1 Mouse anti-Human Monoclonal (4F2C12) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µl/$459
NEP / DDR1 Rabbit anti-Human Polyclonal (pTyr513) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
NEP / DDR1 Rabbit anti-Human Polyclonal (aa17-47) Antibody
Rat, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50 µl/$485
NEP / DDR1 Rabbit anti-Human Polyclonal (aa17-47) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
NEP / DDR1 Rabbit anti-Human Polyclonal (aa17-47) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
NEP / DDR1 Mouse anti-Human Monoclonal (Preservative Free) (10B6E5A11) Antibody
Human
ELISA, Flo
Unconjugated, Preservative Free
100 µl/$412
NEP / DDR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NEP / DDR1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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