Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human, Rabbit (tested or 100% immunogen sequence identity)
Monkey, Mouse, Rat, Bat, Dog, Hamster (at least 90% immunogen sequence identity)
IHC - Paraffin (2.5 µg/ml)
Western blot (1:32000) & (0.1 - 0.3 µg/ml)
Specificity and Use
NDRG1 antibody was raised against synthetic peptide GNSAGPKSMEVSC from the C-terminus of human NDRG1 (NP_006087.2; NP_001128714.1). Percent identity by BLAST analysis: Human, Rabbit (100%); Gorilla, Gibbon, Monkey, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat (92%); Marmoset (85%).
Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking.