Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal (IgG1) to Human NCOA3 / SRC-3 / AIB1
Human NCOA3 / SRC-3 / AIB1
Human (tested or 100% immunogen sequence identity)
Protein G purified
Western blot (1 - 5 µg/ml)
Specificity and Use
NCOA3 / SRC-3 / AIB1 antibody was raised against peptide corresponding to the C-terminus of human AIB1 conjugated to keyhole limpet hemocyanin (KLH).
Recognizes human AIB1, a 160 kD protein and member of the SRC-1 family of nuclear receptor coactivators. AIB1 is amplified in breast tumors and pancreatic cancer cell lines. AIB1 interacts with the estrogen receptor to enhance estrogen- dependent transcriptional gene activation.
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity.