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NCBP1 / CBP80

nuclear cap binding protein subunit 1, 80kDa

Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus via its interaction with ALYREF/THOC4/ALY, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC) via its interaction with UPF1, promoting the interaction between UPF1 and UPF2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2 and is required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of PARN, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, NCBP1/CBP80 does not bind directly capped RNAs (m7GpppG-capped RNA) but is required to stabilize the movement of the N-terminal loop of NCBP2/CBP20 and lock the CBC into a high affinity cap-binding state with the cap structure.

Gene Name: nuclear cap binding protein subunit 1, 80kDa
Synonyms: NCBP1, CBP80, NCBP, NCBP 80 kDa subunit, Sto1
Target Sequences: NM_002486 NP_002477.1 Q09161

☰ Filters
Antibodies (26)
Proteins (6)
ELISA Kits (1)
Cell-Based (1)
Over-Expression Lysate (2)
Primary (26)
Recombinant (4)
NCBP1 / CBP80 (33)
Human (27)
Mouse (12)
Rat (10)
Bovine (3)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Monkey (3)
Pig (3)
Rabbit (3)
Xenopus (3)
IHC (8)
IHC-P (4)
WB (25)
ELISA (12)
ICC (1)
IF (1)
IP (3)
Peptide-ELISA (2)
rabbit (25)
mouse (1)
Product Group
IHCPlus (1)
IgG (16)
IgG2b,k (1)
monoclonal mc (1)
polyclonal pc (25)
1E9 (1)
96-Well Microplate (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (18)
aa647-675 (7)
N-Terminus (6)
aa1-50 (2)
aa482-532 (2)
1-80 aa, N-terminal (1)
Arg5 (1)
No (33)
Adherent Cell Cultures (1)
GST (2)
GST, N-terminus (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
HEK 293 Cells (2)
Wheat Germ Extract (3)
Purified (2)
NCBP1 / CBP80 Antibody - Detection of Human NCBP1/CBP80 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-NCBP1/CBP80 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa482-532) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
NCBP1 / CBP80 Antibody - Anti-NCBP1 / CBP80 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
NCBP1 / CBP80 Protein - 12.5% SDS-PAGE of human NCBP1 stained with Coomassie Blue
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Wheat Germ Extract
GST
118.2 kDa
10 µg/$479; 25 µg/$670
NCBP1 / CBP80 Antibody - Western blot of CBP80 antibody
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (1-80 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NCBP1 / CBP80 Antibody - Detection of Human NCBP1/CBP80 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NCBP1/CBP80 used at a dilution of 1:200 (1 ug/ml). Detection: DAB.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
NCBP1 / CBP80 Antibody - Staining HT29 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NCBP1 / CBP80 Antibody - Immunohistochemical analysis of CBP80 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
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NCBP1 / CBP80 Mouse anti-Human Monoclonal (1E9) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
NCBP1 / CBP80 Antibody - Western blot of CBP80 (R5) pAb in extracts from HeLa cells.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (Arg5) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$321; 100 µl/$403
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
0.1 mg/$379
Select
NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa647-675) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa647-675) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa647-675) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa647-675) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa647-675) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa647-675) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
NCBP1 / CBP80 Antibody - Detection of Human NCBP1/CBP80 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-NCBP1/CBP80 used at a dilution of 1:250.
Select
NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa482-532) Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
2.5 µg/$295; 100 µl/$532
NCBP1 / CBP80 Antibody - Western blot analysis of extracts from HT-29 cells and LOVO cells, using NCBP1 antibody.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
NCBP1 / CBP80 Antibody - Western blot analysis of lysates from HT-29 and LOVO cells, using NCBP1 Antibody. The lane on the right is blocked with the synthesized peptide.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa1-50) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
NCBP1 / CBP80 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$386
Select
NCBP1 / CBP80 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
NCBP1 / CBP80 Antibody - NCBP1 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
NCBP1 / CBP80 Antibody - NCBP1 antibody Western blot of 293T cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Pig, Rabbit, Dog, Bovine, Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
NCBP1 / CBP80 Antibody - NCBP1 Antibody western blot of 293 cell line lysates (35 ug/lane). The NCBP1 antibody detected the NCBP1 protein (arrow).
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NCBP1 / CBP80 Rabbit anti-Human Polyclonal (aa647-675) Antibody
Human
WB
Unconjugated
400 µl/$393
Viewing 1-25 of 33 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).