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Anti-NCAM / CD56 Antibody (clone MOC-1) LS-C134863

Ordering

Wt. Vol. Conc. Price
- 1000 µl - $265
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular NCAM / CD56 Antibodies

Anti-NCAM / CD56 Antibody LS-C5383
Rabbit Polyclonal (IgG) to Chicken NCAM / CD56
Chicken, Human, Mouse, Rat
IHC, Immunofluorescence, Western blot, ELISA, Functional Assay
Unconjugated
Anti-NCAM / CD56 Antibody (aa20-718, clone 1G4) IHC-plus™ LS-B12970
Mouse Monoclonal [clone 1G4] (IgG1) to Human NCAM / CD56
Human, Monkey, Mouse, Rat, Dog
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry - Paraffin Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone MOC-1] (IgG1) to Human NCAM / CD56
Human
IHC - Frozen, Flow Cytometry
Unconjugated

Details

Human NCAM / CD56
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [MOC-1]
Unconjugated
Tissue culture supernatant
Unmodified

Applications

  • IHC - Frozen
  • Flow Cytometry

Specificity and Use

MOC-1 detects an isoform of the neural cell adhesion molecule (NCAM) expressed on natural killer (NK) cells of approximately 145 kD. NK cells make up approximately 10%-25% of peripheral blood lymphocytes, In addition, NCAM is expressed on a variety of neural tissues and some tumors of neuron-endocrine origin, such as small cell lung cancer (SCLC). The CD56 antigen is not expressed on other immune cells. NK cells form a distinct subpopulation of lymphocytes, which are capable of performing their cytotoxic activity without MHC restriction. Target cells may include virally infected cells or transformed cells and CD56 appears to be involved in the cytotoxic activity of NK cells. Certain subtypes of T cell lymphomas may express the CD56 antigen. These include peripheral T cell lymphoma (NK cell lymphoma: CD56+, EBV+) and T lymphocytic lymphoma (CD56+/-).
CD56 (MOC-1) can be applied in flow cytometry for analysis of blood samples and in immunohistochemistry using frozen sections and bone marrow aspirates. CD56 is applied in flow cytometry for the detection of NK cells in immune monitoring. In addition, the neoplastic counterpart of the NK cell can be characterized as T gamma lymphocytosis, showing expression of a number of antigens, e. g. CD56+, CD7+, CD16+, CD2+/- and CD8+/-. Co-expression of CD56 and CD138 )B-B4) is an indication of plasma cell malignancy in multiple myeloma, although it does not occur in all samples. In lung tumors, MOC-1 antibody is helpful in discriminating SCLC from non SCLC. The antibody is effectiveness formulated for direct immunofluorescent staining of human tissue for flow cytometric analysis using 10 ul/106 leukocytes. Since applications vary, each investigator should titrate the reagent to obtain optimal results.

Packaging

Tissue culture supernatant, 0.01 M sodium phosphate, 0.15 M sodium chloride, pH 7.3, 0.2% BSA, 0.09% sodium azide
Store at 4°C.
For research use only.

About NCAM / CD56

P13591 NM_000615 NP_000606.3

NCAM1 Antibody, CD56 Antibody, CD56 antigen Antibody, MSK39 Antibody, NCAM-1 Antibody, N-CAM-1 Antibody, NCAM Antibody

NCAM / CD56 is a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance.

Requested From: United States
Date Requested: 12/3/2016

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