NAR / CPSF4

cleavage and polyadenylation specific factor 4, 30kDa

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

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Products

Antibodies (22)

Proteins (9)

Type

Over-Expression Lysate (5)

Primary (22)

Recombinant (4)

Target

NAR / CPSF4 (31)

Reactivity

Human (21)

Mouse (7)

Rat (5)

Bat (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Pig (3)

Application

IHC (4)

IHC-P (1)

WB (22)

ELISA (9)

IF (1)

IP (3)

Peptide-ELISA (1)

Host

rabbit (20)

mouse (2)

Isotype

IgG (19)

IgG1 (1)

Clonality

monoclonal mc (1)

polyclonal pc (21)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (14)

Epitope

aa96-123 (7)

C-Terminus (4)

N-Terminus (1)

aa220-245 (1)

aa245-269 (1)

Publications

No (31)

Tag

GST (1)

GST, N-terminus (1)

GST, N-terminus + His, C-terminus (1)

His (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Source

293T Cells (3)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (3)

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NAR / CPSF4 Antibody (aa220-245) LS-C288375

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa220-245) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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NAR / CPSF4 Antibody LS-C753702

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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NAR / CPSF4 Antibody LS-C675583

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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NAR / CPSF4 Antibody LS-C810097

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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NAR / CPSF4 Antibody (aa96-123) LS-C320569

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa96-123) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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NAR / CPSF4 Antibody (aa96-123, Biotin) LS-C208602

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa96-123) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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NAR / CPSF4 Antibody (aa96-123, FITC) LS-C208603

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa96-123) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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NAR / CPSF4 Antibody (aa96-123, APC) LS-C208601

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa96-123) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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NAR / CPSF4 Antibody (aa96-123, PE) LS-C208605

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa96-123) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

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NAR / CPSF4 Antibody (aa96-123, Azide-free, HRP) LS-C208604

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa96-123) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

NAR / CPSF4 Antibody LS-C404837

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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NAR / CPSF4 Antibody (N-Terminus) LS-C144913

Antibody:

NAR / CPSF4 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody

Reactivity:

Rat

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

Select

NAR / CPSF4 Antibody (aa245-269) LS-C288377

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa245-269) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

NAR / CPSF4 Antibody LS-C79402

Antibody:

NAR / CPSF4 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$786

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NAR / CPSF4 Antibody LS-C155429

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$450

Select

NAR / CPSF4 Antibody LS-C496991

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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NAR / CPSF4 Antibody (aa96-123) LS-C167005

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (aa96-123) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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NAR / CPSF4 Antibody (C-Terminus) LS-C30443

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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NAR / CPSF4 Antibody (C-Terminus, HRP) LS-C440897

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

NAR / CPSF4 Antibody (C-Terminus, Biotin) LS-C440896

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

NAR / CPSF4 Antibody (C-Terminus, FITC) LS-C440898

Antibody:

NAR / CPSF4 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Mouse, Dog, Guinea pig, Rat, Pig, Horse, Bat, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

NAR / CPSF4 Antibody LS-C307075

Antibody:

NAR / CPSF4 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µg/$705

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Human NAR / CPSF4 Protein (Recombinant GST, N-terminus) (aa1-244) - LS-G56178

Source:

E. coli

Tag:

GST, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human NAR / CPSF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86157

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.1 kDa

Price:

20 µg/$150

Select

Human NAR / CPSF4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86155

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.4 kDa

Price:

20 µg/$150

Viewing 1-25 of 31 product results

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