NANOG

Nanog homeobox

Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

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Products

Antibodies (106)

Proteins (15)

ELISA Kits (6)

Type

Custom (3)

Over-Expression Cell Culture Supernatant (1)

Over-Expression Lysate (3)

Primary (106)

Recombinant (11)

Sandwich (3)

Target

NANOG (127)

Reactivity

Human (102)

Mouse (18)

Rat (7)

Bovine (6)

Chimpanzee (15)

Gibbon (15)

Goat (1)

Macaque (1)

Monkey (15)

Orangutan (3)

Pig (3)

Sheep (6)

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Application

IHC (20)

IHC-P (11)

WB (81)

Flo (9)

DB (14)

ELISA (48)

ICC (13)

IF (30)

IP (4)

Peptide-ELISA (7)

Host

rabbit (92)

mouse (11)

goat (3)

Product Group

IHCPlus (2)

PathPlus Cancer (2)

Isotype

IgG (58)

IgG1 (8)

IgG2a,k (2)

Clonality

monoclonal mc (11)

polyclonal pc (95)

Clone

1E6C4 (3)

2C4 (1)

5A10 (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (5)

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APC Conjugated (5)

Azide-free (4)

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Concentrated (1)

Cy3 Conjugated (1)

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FITC Conjugated (12)

HRP Conjugated (12)

PE Conjugated (5)

Preservative Free (1)

Ready-to-Use (1)

Unconjugated (57)

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Epitope

aa1-305 (8)

aa24-73 (8)

Ser285 (7)

aa94-123 (7)

pSer285 (7)

pSer71 (7)

aa135-184 (4)

aa21-70 (4)

aa35-84 (4)

aa1-50 (3)

aa1-154 (2)

aa20-166 (2)

Amino Acid: 20-166 (1)

C-Terminus (1)

Internal Region (1)

aa144-157 (1)

aa15-49 (1)

aa155-189 (1)

aa250-C-term (1)

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Publications

No (126)

Yes (1)

Sample Type

Cell Lysates (1)

Plasma (2)

Serum (2)

Tissue Homogenates (2)

Tag

6His, N-terminus (2)

6His-SUMO, N-terminus (1)

GST, N-terminus (2)

His (1)

His, N-Terminal (2)

His-GST (1)

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Species

Human (12)

Mouse (2)

Source

293T Cells (1)

E. coli (8)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (7)

Low Endotoxin Level

Low endotoxin level (2)

Select

PathPlus™ NANOG Antibody (aa94-123) LS-B3425

Cancer

(5.0) Rating

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa94-123) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$440

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IHC-plus™ NANOG Antibody (aa291-304) LS-B3017

(4.0) Rating

Antibody:

NANOG Goat anti-Human Polyclonal (aa291-304) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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NANOG Antibody (aa144-157) LS-C55142

(4.4) Rating

(5) Publication(s)

Antibody:

NANOG Goat anti-Human Polyclonal (aa144-157) Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

NANOG Antibody (clone 1E6C4) LS-C108845

Antibody:

NANOG Mouse anti-Human Monoclonal (1E6C4) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µl/$435

Select

NANOG Antibody (aa15-49) LS-C98243

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa15-49) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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PathPlus™ NANOG Antibody (Concentrated) LS-B16192

Cancer

(5.0) Rating

Antibody:

NANOG Mouse anti-Human Monoclonal (Concentrated) Antibody

Reactivity:

Human

Applications:

ELISA, IHC-P

Format:

Unconjugated, Concentrated

Price:

0.05 ml/$460

Select

NANOG Antibody (clone 2C4) LS-C348865

Antibody:

NANOG Mouse anti-Human Monoclonal (2C4) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

100 µl/$346

Select

NANOG Antibody (aa94-123) LS-C323228

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa94-123) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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NANOG Antibody (aa94-123, Biotin) LS-C520377

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa94-123) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

NANOG Antibody (aa94-123, FITC) LS-C263953

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa94-123) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

NANOG Antibody (aa94-123, Azide-free, HRP) LS-C263954

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa94-123) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

NANOG Antibody (aa94-123, APC) LS-C263952

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa94-123) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

NANOG Antibody (aa94-123, PE) LS-C263957

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa94-123) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

Select

NANOG Antibody (aa20-166, clone 1E6C4) LS-C359267

Antibody:

NANOG Mouse anti-Human Monoclonal (aa20-166) (1E6C4) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

Unconjugated

Price:

0.1 ml/$386

Select

IHC-plus™ NANOG Antibody LS-B8225

(4.0) Rating

Antibody:

NANOG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$485

Select

NANOG Antibody (Biotin) LS-C104594

Antibody:

NANOG Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

25 µg/$356; 50 µg/$396

• Unconjugated
• Biotin

• Unconjugated
• Biotin

Select

NANOG Antibody (Amino Acid: 20-166, clone 1E6C4) LS-C758745

Antibody:

NANOG Mouse anti-Human Monoclonal (Amino Acid: 20-166) (1E6C4) Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$541

Select

NANOG Antibody (aa135-184, FITC) LS-C426097

Antibody:

NANOG Rabbit anti-Human Polyclonal (aa135-184) (FITC) Antibody

Reactivity:

Sheep, Bovine, Human, Monkey, Chimpanzee, Orangutan, Gibbon

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

Select

NANOG Antibody LS-C108536

Antibody:

NANOG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC-P, WB

Format:

Unconjugated

Price:

0.1 mg/$460

Select

NANOG Antibody (Ser285, FITC) LS-C263948

Antibody:

NANOG Rabbit anti-Human Polyclonal (Ser285) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

NANOG Antibody (Ser285, APC) LS-C263947

Antibody:

NANOG Rabbit anti-Human Polyclonal (Ser285) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

NANOG Antibody (Ser285, PE) LS-C263950

Antibody:

NANOG Rabbit anti-Human Polyclonal (Ser285) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

NANOG Antibody (Ser285, Azide-free, HRP) LS-C263949

Antibody:

NANOG Rabbit anti-Human Polyclonal (Ser285) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• FITC
• APC
• PE
• HRP, Azide-free

• FITC
• APC
• PE
• More...
  • HRP, Azide-free

Select

NANOG Antibody LS-C488377

Antibody:

NANOG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

20 µl/$256; 100 µl/$412

Select

NANOG Antibody LS-C109328

Antibody:

NANOG Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$450

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