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Anti-NALP3 / NLRP3 Antibody (aa4-223) LS-C150009


Wt. Vol. Conc. Price
100 µg - - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular NALP3 / NLRP3 Antibodies

Anti-NALP3 / NLRP3 Antibody (aa1024-1036) IHC-plus™ LS-B1766
Goat Polyclonal to Human NALP3 / NLRP3
IHC - Paraffin, ELISA
Immunohistochemistry Image
Anti-NALP3 / NLRP3 Antibody (aa1-50) LS-C148764
Rabbit Polyclonal to Human NALP3 / NLRP3
Human, Monkey, Mouse, Rat
Western blot

100% Guaranteed 100% Guaranteed
Sheep Polyclonal (IgG) to Human NALP3 / NLRP3
ICC, Western blot


Human NALP3 / NLRP3
Human (tested or 100% immunogen sequence identity)
IgG Polyclonal
Immunoaffinity purified


  • ICC (5 - 15 µg/ml)
  • Western blot (0.5 µg/ml)

Specificity and Use

NALP3 / NLRP3 antibody was raised against e. coli-derived recombinant human NALP3 Ala4-Val223 Accession # Q96P20.
Detects human NALP3 in direct ELISAs and Western blots. In direct ELISAs, less than 1 % cross-reactivity with recombinant human (rh).


Lyophilized from 0.2 um filtered solution in PBS, trehalose
Sterile PBS. Resuspend to 500 ul
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
For research use only.

About NALP3 / NLRP3

Q96P20 NM_004895 NP_004886.3

NLRP3 Antibody, AGTAVPRL Antibody, AII Antibody, C1orf7 Antibody, Caterpiller protein 1.1 Antibody, Cryopyrin Antibody, FCAS Antibody, FCU Antibody, PYPAF1 Antibody, NALP3 Antibody, CIAS1 Antibody, CLR1.1 Antibody, MWS Antibody

NALP3 / NLRP3 is a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis.


NALP3 in THP-1 Human Cell Line. NALP3 was detected in immersion fixed THP-1 human acute monocytic leukemia cells, unstimulated (lower panel) and stimulated (upper panel) with PMA and LPS, using Sheep Anti-Human NALP3 Antigen Affinity-purified Polyclonal Antibody at 10 ug/ml for 3 hours at room temperature. Cells were stained using NorthernLights 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm.

Western blot

Western blot
Detection of Human NALP3 by Western Blot. Western blot shows lysates of HEK293 human embryonic kidney cell line either mock transfected, transfected with human NALP1 or transfected with NALP3 and THP-1 human acute monocytic leukemia cell line untreated (-) or treated (+) with 20 ng/ml PMA for 72 hours and 1 ug/ml LPS for 24 hours. PVDF Membrane was probed with 0.5 ug/ml of Sheep Anti-Human NALP3 Antigen Affinity-purified Polyclonal Antibody followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody. A specific band was detected for NALP3 at approximately 115 kD (as indicated). This experiment was conducted under reducing conditions.

Requested From: United States
Date Requested: 10/25/2016

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