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NAG20 / UBAP1 is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene Name: | ubiquitin associated protein 1 |
Synonyms: | UBAP1, UAP, UBAP-1, Ubiquitin-associated protein 1, Ubiquitin associated protein, NAG20, UBAP, Ubiquitin associated protein 1 |
Target Sequences: | NM_016525 NP_057609.2 Q9NZ09 |
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