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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MVP / VAULT1 Antibody (clone 1027) LS‑C202627
Antibody
VAULT1 antibody LS-C202627 is an unconjugated mouse monoclonal antibody to mouse VAULT1 (MVP). Validated for ELISA, Flow, IHC, IP and WB.
Catalog
Size
Price
LS-C202627-100
100 µg (0.1 mg/ml)
Unavailable

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Product Description

VAULT1 antibody LS-C202627 is an unconjugated mouse monoclonal antibody to mouse VAULT1 (MVP). Validated for ELISA, Flow, IHC, IP and WB.
About MVP / VAULT1
MVP / VAULT1 is the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Q14764 NM_017458 NP_059447.2

MVP Antibody, Major vault protein Antibody, VAULT1 Antibody, LRP Antibody


Specifications

Target
Mouse MVP / VAULT1
Host
Mouse
Reactivity
Mouse (tested or 100% immunogen sequence identity)
Clonality
IgM Monoclonal [1027]
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin
  • IHC - Frozen
  • Western blot
  • Immunoprecipitation
  • Flow Cytometry
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
MVP / VAULT1 antibody was raised against 5 ug of affinity purified nuclear extract proteins. Spleen cells were fused with equal number of Sp0Ag-14 myeloma cells. Cells whose supernatant showed a positive signal for a 104-kD band were selected and cloned by limited dilution.
Specificity
Clone 1027 is specific for a 104-kD protein. This mAb is one of four mAb which recognize different epitopes of the protein. This 104-kD protein is the major vault protein (MVP) also described as the lung resistance protein (LRP) and has shown to interact with the estrogen receptor. The protein is part of a very large vault ribonucleoprotein complex present in all eukaryotic cells and its structure and protein composition is highly conserved. Because of the size, shape, and protein and RNA composition of this complex the particles are different from other ribonucleoproteins. Source: A BALB/c mouse was immunized with 5 gg of affinity purified nuclear extract proteins. Spleen cells were fused with equal number of Sp0Ag-14 myeloma cells. Cells whose supernatant showed a positive signal for a 104-kD band were selected and cloned by limited dilution.
Presentation
PBS, 0.05% sodium azide
Storage
Store at 4°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/24/2018

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