MUL1 / MULAN

mitochondrial E3 ubiquitin protein ligase 1

Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abilty to sumoylate DNM1L. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.

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Products

Antibodies (22)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (22)

Recombinant (1)

Target

MUL1 / MULAN (25)

Reactivity

Human (22)

Mouse (7)

Rat (1)

Bat (3)

Bovine (3)

Chimpanzee (6)

Dog (6)

Gibbon (3)

Guinea pig (6)

Horse (6)

Monkey (6)

Rabbit (6)

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Application

IHC (3)

WB (21)

ELISA (8)

IF (2)

Peptide-ELISA (1)

Host

rabbit (21)

mouse (1)

Isotype

IgG (14)

IgG1 (1)

Clonality

monoclonal mc (1)

polyclonal pc (21)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (11)

Epitope

aa272-301 (7)

aa143-192 (4)

aa216-265 (4)

aa176-210 (1)

Publications

No (25)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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MUL1 / MULAN Antibody (aa176-210) LS-C344409

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa176-210) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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MUL1 / MULAN Antibody (aa143-192) LS-C110775

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa143-192) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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MUL1 / MULAN Antibody (aa143-192, HRP) LS-C444966

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa143-192) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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MUL1 / MULAN Antibody (aa143-192, Biotin) LS-C444964

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa143-192) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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MUL1 / MULAN Antibody (aa143-192, FITC) LS-C444965

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa143-192) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Horse, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

MUL1 / MULAN Antibody (aa272-301) LS-C164681

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa272-301) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

MUL1 / MULAN Antibody LS-C748186

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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MUL1 / MULAN Antibody LS-C833049

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

MUL1 / MULAN Antibody LS-C753740

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

MUL1 / MULAN Antibody (aa272-301) LS-C329860

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa272-301) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

MUL1 / MULAN Antibody (aa272-301, Biotin) LS-C208973

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa272-301) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

MUL1 / MULAN Antibody (aa272-301, FITC) LS-C207279

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa272-301) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

MUL1 / MULAN Antibody (aa272-301, APC) LS-C208972

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa272-301) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

MUL1 / MULAN Antibody (aa272-301, Azide-free, HRP) LS-C207280

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa272-301) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

MUL1 / MULAN Antibody (aa272-301, PE) LS-C207281

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa272-301) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

MUL1 / MULAN Antibody LS-C781020

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

MUL1 / MULAN Antibody LS-C804190

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

MUL1 / MULAN Antibody LS-C783192

Antibody:

MUL1 / MULAN Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

25 µg/$288; 100 µg/$414

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MUL1 / MULAN Antibody (aa216-265) LS-C102020

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa216-265) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

MUL1 / MULAN Antibody (aa216-265, HRP) LS-C444969

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa216-265) (HRP) Antibody

Reactivity:

Rabbit, Dog, Guinea pig, Bovine, Horse, Bat, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

MUL1 / MULAN Antibody (aa216-265, Biotin) LS-C444967

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa216-265) (Biotin) Antibody

Reactivity:

Rabbit, Dog, Guinea pig, Bovine, Horse, Bat, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

MUL1 / MULAN Antibody (aa216-265, FITC) LS-C444968

Antibody:

MUL1 / MULAN Rabbit anti-Human Polyclonal (aa216-265) (FITC) Antibody

Reactivity:

Rabbit, Dog, Guinea pig, Bovine, Horse, Bat, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

Human MUL1 / MULAN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86501

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.6 kDa

Price:

20 µg/$150

Select

Human MUL1 / MULAN Protein (Recombinant GST) (Full Length) - LS-G35206

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

64.46 kDa

Price:

10 µg/$479; 25 µg/$670

Select

MUL1 / MULAN Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109932

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.6 kDa

Price:

100 µg/$494

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