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Anti-MUC16 / CA125 Antibody (Extracellular Domain, clone X75) LS-C58422

Note: This antibody replaces LS-C77441, LS-C142315


Wt. Vol. Conc. Price
200 µg - - $330
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular MUC16 / CA125 Antibodies

Anti-MUC16 / CA125 Antibody (PE) LS-C77440
Mouse Monoclonal (IgG1) to Human MUC16 / CA125
PE Conjugated
Anti-MUC16 / CA125 Antibody LS-C84289
Mouse Monoclonal (IgG1) to Human MUC16 / CA125
Anti-MUC16 / CA125 Antibody IHC-plus™ LS-B5264
Mouse Monoclonal (IgG1) to Human MUC16 / CA125
IHC - Paraffin, ELISA
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone X75] (IgG1) to Human MUC16 / CA125
Western blot, ELISA


Human MUC16 / CA125
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [X75]
Ion exchange chromatography


  • Western blot

Specificity and Use

MUC16 / CA125 antibody was raised against cA125 antigen purified from human ovarian carcinoma.
Extracellular Domain
Recognizes the ovarian cancer mucin CA125 (also known as MUC16). CA125 consists of a short cytoplasmic tail, a transmembrane domain and an exceptionally large glycosylated extracellular domain. The extracellular domain is dominated by a large number of 156-amino acid repeat units, over 60 in all. These repeats are known to bind the antibodies OC125 and M11. CA125 is present within normal ovarian, endometrium, endocervix and fallopian tissue, but levels are elevated in over 90% of women with advanced ovarian cancer. CA125 levels may also be elevated in other cancers and non-cancerous conditions such as peritonitis, endometriosis and liver cirrhosis. Levels may also fluctuate during the menstrual cycle and occasionally increases in pregnancy, making CA125 an unreliable marker for ovarian cancer in premenopausal women. The function of CA125 in healthy tissue is unknown but it is thought to provide a protective lubricating barrier against particles and infectious agents at mucosal surfaces. CA125 was concluded by the International Society of Oncology and BioMarkers (ISOBM) to contain two major antigenic domains. Recognizes the epitope specificity group B, similar to the M-11 antibody. May be used as a capture antibody in ELISA assays.
ELISA: This product may be used in an indirect ELISA or as a detection antibody in a sandwich ELISA together with LS-B2829 as a capture reagent.


PBS, 0.09% sodium azide.
Long term: -20°C; Short term: -20°C
For research use only.

About MUC16 / CA125

Q8WXI7 NM_024690 NP_078966.2

MUC16 Antibody, CA125 ovarian cancer antigen Antibody, CA125 Antibody, CA-125 Antibody, MUC-16 Antibody, Mucin-16 Antibody

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Requested From: United States
Date Requested: 10/22/2016

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