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Anti-MTNR1B / MT2 Antibody (aa334-348) IHC-plus™ LS-B7370

Note: This antibody replaces LS-C112709

Catalog	Size	Price
LS-B7370-50	50 µg (0.5 mg/ml)	Unavailable

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Anti-MTNR1B / MT2 Antibody (Cytoplasmic Domain) IHC-plus™ LS-A932

Antibody:	Rabbit Polyclonal to Human MTNR1B / MT2
Reactivity:	Human
Application:	IHC - Paraffin
Format:	Unconjugated

Anti-MTNR1B / MT2 Antibody (Extracellular Domain) IHC-plus™ LS-A934

Antibody:	Rabbit Polyclonal to Human MTNR1B / MT2
Reactivity:	Human, Monkey
Application:	IHC - Paraffin
Format:	Unconjugated

Anti-MTNR1B / MT2 Antibody (N-Terminus) IHC-plus™ LS-A930

Antibody:	Rabbit Polyclonal to Human MTNR1B / MT2
Reactivity:	Human
Application:	IHC - Paraffin, ELISA
Format:	Unconjugated

Anti-MTNR1B / MT2 Antibody (C-Terminus) IHC-plus™ LS-A933

Antibody:	Rabbit Polyclonal to Human MTNR1B / MT2
Reactivity:	Human
Application:	IHC - Paraffin, ELISA
Format:	Unconjugated

Anti-MTNR1B / MT2 Antibody (aa334-348) IHC-plus™ LS-B7370

Antibody:	Goat Polyclonal to Human MTNR1B / MT2
Reactivity:	Human
Application:	IHC - Paraffin, ELISA
Format:	Unconjugated

Antibody:	Goat Polyclonal to Human MTNR1B / MT2
Reactivity:	Human
Application:	IHC - Paraffin, ELISA
Format:	Unconjugated

Details

Target:	Human MTNR1B / MT2
Host:	Goat
Reactivity:	Human (tested or 100% immunogen sequence identity)
Clonality:	Polyclonal
Conjugations:	Unconjugated
Purification:	Immunoaffinity purified
Modifications:	Unmodified

Applications

Approved:

IHC - Paraffin (3.75 µg/ml)
ELISA (1:32000)

Specificity and Use

Immunogen:

MTNR1B / MT2 antibody was raised against synthetic peptide C-QDASKGSHAEGLQSP from the C-terminus of human MTNR1B (NP_005950.1). Percent identity by BLAST analysis: Human, Gorilla (100%); Monkey (87%); Elephant (80%).

Blocking Peptide:

LS-E26943 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-B7370. Useful for pre-absorption and neutralization of the antibody's antigen binding site.

Epitope:

aa334-348

Specificity:

Human MTNR1B.

Usage:

Peptide ELISA: antibody detection limit dilution 1:32000. Western blot: Preliminary experiments gave approx .48kDa and 37kDa bands in Human Brain (Cerebellum) lysates after 1 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 40.2kDa according to NP_005950.1. The 48kDa and 37kDa bands were successfully blocked by incubation with the immunizing peptide.

Packaging

Presentation:	Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Storage:	Store at -20°C. Minimize freezing and thawing.
Restrictions:	For research use only.

About MTNR1B / MT2

Uniprot: P49286 NCBI: NM_005959 NP_005950.1

Synonyms: MTNR1B Antibody, MEL-1B-R Antibody, Mel-1b melatonin receptor Antibody, Melatonin receptor 1B Antibody, Melatonin receptor MEL1B Antibody, Mt2r Antibody, MT2 melatonin receptor Antibody, MtT2 receptor Antibody, Melatonin receptor type 1B Antibody, MT2 Antibody, FGQTL2 Antibody, Mel1b receptor Antibody

Description: MTNR1B / MT2 is one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This gene product is an integral membrane protein that is a G-protein coupled, 7-transmembrane receptor. It is found primarily in the retina and brain although this detection requires RT-PCR. It is thought to participate in light-dependent functions in the retina and may be involved in the neurobiological effects of melatonin.

(More About MTNR1B / MT2)

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Immunohistochemistry

Anti-MTNR1B antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7370 concentration 3.75 ug/ml.

Requested From:
Date Requested: 6/25/2017

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