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| Catalog Number | Size | Price |
|---|---|---|
| LS-A7186-50 | 50 µg (1 mg/ml) | $460 |
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PathPlus™ Polyclonal Rabbit anti‑Human MST1R / RON Antibody (C‑Terminus, IHC) LS‑A7186
PathPlus™ Polyclonal Rabbit anti‑Human MST1R / RON Antibody (C‑Terminus, IHC) LS‑A7186
Antibody:
MST1R / RON Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
MST1R / RON Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Macrophage stimulating 1 receptor (c-met-related tyrosine kinase, MST1R) regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, it interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. It also plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human MST1R / RON
Synonyms
MST1R | C-met-related tyrosine kinase | CD136 | CDw136 | CD136 antigen | Friend virus susceptibility 2 | Fv2 | MSP receptor | p185-Ron | PTK8 protein tyrosine kinase 8 | RON | Soluble RON variant 3 | Soluble RON variant 1 | MST1R variant RON30 | Oncogene RON | PTK8 | MST1R variant RON62 | Protein-tyrosine kinase 8 | RON variant E2E3 | Soluble RON variant 2 | Soluble RON variant 4
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 18 amino acid peptide from C-Terminus of human MST1R / RON. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Marmoset (94%); Mouse, Rat, Hamster, Elephant, Panda, Horse (89%); Dog, Bat (83%).
Epitope
C-Terminus
Specificity
Human MST1R / RON. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (4 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About MST1R / RON
Validation
Bone marrow, macrophages
Bone marrow, macrophages
Small Intestine, Crohn's Disease
Small Intestine, Crohn's Disease
Brain Cortex Neuron
Brain Cortex Neuron
Lung, Bronchitis
Lung, Bronchitis
Anti-MST1R / RON antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MST1R / RON antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MST1R / RON antibody IHC of human colon carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MST1R / RON antibody IHC of human colon carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MST1R / RON antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MST1R / RON antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ MST1R / RON Antibody (C-Terminus) for IHC LS-A7186 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin, ELISA
Species:
Mouse
Applications:
IHC, IHC - Paraffin, Western blot
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
