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MSR1 / CD204
macrophage scavenger receptor 1
MSR1 / CD204 is a member of the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
| Gene Name: | macrophage scavenger receptor 1 |
| Synonyms: | MSR1, CD204 antigen, SCARA1, PhSR1, SR-A, CD204, PhSR2, SRA, MSR2 |
| Target Sequences: | NM_002445 NP_002436.1 P21757 |
Publications (3)
1
Age-associated and therapy-induced alterations in the cellular microenvironment of experimental gliomas. Schneider H, Lohmann B, Wirsching HG, Hasenbach K, Rushing EJ, Frei K, Pruschy M, Tabatabai G, Weller M. Oncotarget. 2017 August;8:87124-87135. (Mouse)
[Full Text Article]
[PubMed:29152068]
[PMC:PMC5675620]
2
Tumor-associated macrophages induce invasion and poor prognosis in human gastric cancer in a cyclooxygenase-2/MMP9-dependent manner. Xu J, Yu Y, He X, Niu N, Li X, Zhang R, Hu J, Ma J, Yu X, Sun Y, Ni H, Wang F. American journal of translational research. 2019 September;11:6040-6054. [Full Text Article]
[PubMed:31632572]
[PMC:PMC6789263]
Related Antibodies: LS-C336674.
3
The phosphodiesterase 4 inhibitor AA6216 suppresses activity of fibrosis-specific macrophages. Takashi Matsuhira , Osamu Nishiyama, Yuji Tabata, Shinji Kurashimo, Hiroyuki Sano, Takashi Iwanaga, Yuji Tohda. Biochemistry and biophysics reports. 2021 Aug;28:101118. [Full Text Article]
[PubMed:34485715]
[PMC:PMC8408426]
Related Antibodies: LS-C43466.
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MSR1 / CD204 Mouse anti-Human Monoclonal (aa197-451) (OTI9E5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
MSR1 / CD204 Mouse anti-Human Monoclonal (aa197-451) (Carrier-free) (OTI9E5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MSR1 / CD204 Rat anti-Mouse Monoclonal Antibody
Mouse
ELISA, Flo, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$562; 250 µg/$755
MSR1 / CD204 Rat anti-Mouse Monoclonal (HRP) Antibody
Mouse
ELISA, Flo, IF, IHC, IP, WB
HRP Conjugated
100 µl/$836
MSR1 / CD204 Rat anti-Mouse Monoclonal (FITC) (2F8) Antibody
Mouse
Flo
FITC Conjugated
50 µg/$534; 100 µg/$725; 500 µg/$984
MSR1 / CD204 Rat anti-Mouse Monoclonal (Extracellular Domain) (APC) (268318) Antibody
Mouse
Flo
APC Conjugated
100 Tests/$896
MSR1 / CD204 Rat anti-Mouse Monoclonal (PE) (10B1015) Antibody
Channel catfish, Mouse, Pig
Flo
PE Conjugated
100 Tests/$755
Neuroscience
MSR1 / CD204 Mouse anti-Human Monoclonal (aa197-451) (8C11) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MSR1 / CD204 Mouse anti-Human Monoclonal (2G8) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
MSR1 / CD204 Rat anti-Mouse Monoclonal (Extracellular Domain) (PE) (268318) Antibody
Mouse
Flo
PE Conjugated
100 Tests/$824
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
MSR1 / CD204 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
MSR1 / CD204 Rat anti-Mouse Monoclonal (2F8) Antibody
Channel catfish, Mouse, Pig
ELISA, Flo, IF, IHC, IHC-Fr, IP, WB
Unconjugated
25 µg/$281; 0.1 mg/$385; 0.25 mg/$471
MSR1 / CD204 Rat anti-Mouse Monoclonal (Biotin) (2F8) Antibody
Mouse
Flo
Biotin Conjugated
0.1 mg/$432
MSR1 / CD204 Rat anti-Mouse Monoclonal (FITC) (2F8) Antibody
Mouse
Flo
FITC Conjugated
25 µg/$281; 50 µg/$328; 0.1 mg/$432; 0.5 mg/$570
MSR1 / CD204 Rat anti-Mouse Monoclonal (RPE) (2F8) Antibody
Mouse
Flo
RPE Conjugated
100 Tests/$485
MSR1 / CD204 Rat anti-Mouse Monoclonal (Low Endotoxin) (2F8) Antibody
Mouse
ELISA, Flo, Func, IHC, IHC-Fr, IP, WB
Unconjugated, Low Endotoxin
500 µg/$968
MSR1 / CD204 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
MSR1 / CD204 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
MSR1 / CD204 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
MSR1 / CD204 Rabbit anti-Mouse Polyclonal Antibody
Mouse
Flo, ICC, IF, IHC, IHC-P
Unconjugated
20 µl/$286; 100 µl/$435
MSR1 / CD204 Rabbit anti-Human Polyclonal (aa336-364) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
MSR1 / CD204 Rabbit anti-Human Polyclonal (aa400-450) Antibody
Dog, Horse, Human
WB
Unconjugated
0.1 ml/$386
MSR1 / CD204 Rabbit anti-Human Polyclonal (aa336-364) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
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