Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone MN-1] (IgG) to Human MSLN / Mesothelin
IHC, IHC - Paraffin, Western blot, ELISA
Mouse Monoclonal (IgG1) to Human MSLN / Mesothelin
IHC, IHC - Paraffin
Human MSLN / Mesothelin
Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
IHC - Paraffin
Specificity and Use
Recombinant protein corresponding to the membrane-bound form of the mesothelin molecule.
Recognizes Mesothelin. Species cross-reactivity: Human.
Immunohistology (Formalin/paraffin): (Use Ab at 1:20-1:40 for 30 min at RT) Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min. Positive control: Mesothelioma.
This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described.