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Anti-MSLN / Mesothelin Antibody LS-C44957

Ordering

Wt. Vol. Conc. Price
- 1000 µl - Unavailable

Most Popular MSLN / Mesothelin Antibodies

Anti-MSLN / Mesothelin Antibody (clone 5B2) LS-C87690
Mouse Monoclonal [clone 5B2] (IgG1) to Human MSLN / Mesothelin
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-MSLN / Mesothelin Antibody (clone 295D) LS-C179303
Rat Monoclonal [clone 295D] (IgG2a,k) to Mouse MSLN / Mesothelin
Mouse
Flow Cytometry
Unconjugated
Flow Cytometry Image
Anti-MSLN / Mesothelin Antibody (clone 295D, PE) LS-C179304
Rat Monoclonal [clone 295D] (IgG2a,k) to Mouse MSLN / Mesothelin
Mouse
Flow Cytometry
PE Conjugated
Flow Cytometry Image
Anti-MSLN / Mesothelin Antibody (clone B35) LS-C179484
Rat Monoclonal [clone B35] (IgG2a) to Mouse MSLN / Mesothelin
Mouse
Flow Cytometry
Unconjugated
Flow Cytometry Image
Anti-MSLN / Mesothelin Antibody (Extracellular Domain, clone MN-1) IHC-plus™ LS-B10593
Mouse Monoclonal [clone MN-1] (IgG) to Human MSLN / Mesothelin
Human
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal (IgG1) to Human MSLN / Mesothelin
Human, Cynomolgus monkey
IHC - Frozen
Unconjugated

Details

Human MSLN / Mesothelin
Mouse
Human, Cynomolgus monkey (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Unconjugated
Unmodified

Applications

IHC - Frozen (1:10 - 1:40)

Specificity and Use

MSLN / Mesothelin antibody was raised against spleen lymphocytes from mice fused with ovcar-3.
Binds Mesothelin, a 40kD GPI-anchored cell surface glycoprotein. Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma; ovarian and pancreatic adenocarcinoma. Mesothelin is attached to the cell membrane by a glycosylphosphatidyl inositol linkage and a 31-kD shed fragment named megakaryocyte-potentiating factor (MPF). The biological function of mesothelin is not known. The K1 antibody has been used to differentiate between epithelial malignant mesothelioma and lung adenocarcinomas by immunohistology.

Packaging

Ascites, 0.01 M PBS, 0.09% sodium azide, 1% BSA.
For research use only.

About MSLN / Mesothelin

Q13421 NM_013404 NP_037536.2

MSLN Antibody, CAK1 antigen Antibody, MPF Antibody, SMRP Antibody, Mesothelin Antibody, CAK1 Antibody

This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described.

Requested From: 
Date Requested: 4/27/2017

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