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MSLN / Mesothelin
mesothelin
This gene encodes a preproprotein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Alternative splicing results in multiple transcript variants. Mesothelin is a cell surface differentiation antigen found in mesothelial cells, mesotheliomas and ovarian cancers. Although the function of mesothelin is unknown, it may play a role in cellular adhesion. Three transcript variants have been described. Their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. MPF is a cytokine with megakaryocyte potentiating activity. Mesothelin null mutant mice show a normal phenotype suggesting that mesothelin function is not essential for growth or reproduction in mice (Bera et al., 2000).
| Gene Name: | mesothelin |
| Synonyms: | MSLN, CAK1 antigen, MPF, SMRP, Mesothelin, CAK1 |
| Target Sequences: | NM_013404 NP_037536.2 Q13421 |
Publications (4)
1
New monoclonal antibodies to mesothelin useful for immunohistochemistry, fluorescence-activated cell sorting, Western blotting, and ELISA. Onda M, Willingham M, Nagata S, Bera TK, Beers R, Ho M, Hassan R, Kreitman RJ, Pastan I. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 11:5840-6.
[PubMed:16115924]
Related Antibodies: LS-C154007.
2
A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express a-gal epitopes. Furukawa K, Tanemura M, Miyoshi E, Eguchi H, Nagano H, Matsunami K, Nagaoka S, Yamada D, Asaoka T, Noda T, Wada H, Kawamoto K, Goto K, Taniyama K, Mori M, Doki Y. PloS one. 2017 12:e0184901. (IHC-P; Human)
[Full Text Article]
[PubMed:29077749]
3
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses. Watanabe K, Luo Y, Da T, Guedan S, Ruella M, Scholler J, Keith B, Young RM, Engels B, Sorsa S, Siurala M, Havunen R, Tähtinen S, Hemminki A, June CH. JCI insight. 2018 April;3:pii: 99573. (Mouse)
[Full Text Article]
[PubMed:29618658]
[PMC:PMC5928866]
Related Antibodies: LS-C179484.
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MSLN / Mesothelin
(163)
Reactivity
Human
(103)
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(26)
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MSLN / Mesothelin Mouse anti-Human Monoclonal (MB-G10) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$574
MSLN / Mesothelin Mouse anti-Human Monoclonal (MN-1) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (aa308-576) Antibody
Mouse
IHC, IHC-P
Unconjugated
10 µg/$318; 100 µg/$470
MSLN / Mesothelin Rat anti-Mouse Monoclonal (B35) Antibody
Mouse
Flo
Unconjugated
100 µg/$447
MSLN / Mesothelin Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa540-589) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa540-589) (HRP) Antibody
Mouse, Guinea pig, Bovine, Pig, Gibbon, Human
WB
HRP Conjugated
100 µl/$469
Sandwich
96-Well Strip Plate
Monkey
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
34.9kD
10 µg/$266; 50 µg/$321; 500 µg/$905; 1 mg/$1,369
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (aa345-548) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
MSLN / Mesothelin Rabbit anti-Mouse Polyclonal (aa345-548) (PE) Antibody
Mouse
WB
PE Conjugated
100 µl/$412; 200 µl/$499; 500 µl/$869; 1 ml/$1,030; 2 ml/$1,345; 5 ml/$2,521
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
61kD
10 µg/$277; 50 µg/$386; 500 µg/$1,533; 1 mg/$2,055
Sandwich
12 x 8-Well Microstrips
Human
250 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$618
MSLN / Mesothelin Rat anti-Human Monoclonal Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$951
MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa 37-598) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
HEK 293 Cells
Fc
Less than 1.0 EU/µg protein (determined by LAL method).
60.7 kDa
100 µg/$721
Wheat Germ Extract
GST
94.3 kDa
2 µg/$439
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
MSLN / Mesothelin Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IP, WB
Biotin Conjugated
100 µl/$904
MSLN / Mesothelin Goat anti-Human Polyclonal (aa302-314) Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
MSLN / Mesothelin Rabbit anti-Human Polyclonal (aa395-444) Antibody
Human
WB
Unconjugated
100 µl/$424
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