Human, Mouse, Rat, Dog
(tested or 100% immunogen sequence identity)
- Western blot (1:100 - 1:500)
MSH6 antibody was raised against synthetic human MSH6 peptide.
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. cross reacts with mouse, rat and dog.
0.05% sodium azide
Store at 2-8°C. Do not freeze.
For research use only.
This antibody carries the LSBio 100% Guarantee.