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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MSH6 Antibody (clone 44) LS‑C95606
Antibody
MSH6 antibody LS-C95606 is an unconjugated mouse monoclonal antibody to MSH6 from human, mouse, rat and other species. Validated for IP and WB.
Catalog
Size
Price
LS-C95606-0.5
0.5 ml
Unavailable
LS-C95606-1
1 ml
Unavailable

Popular MSH6 Products

IHC of paraffin-embedded rectum cancer tissues using MSH6 mouse monoclonal antibody with DAB staining.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry, ELISA
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Applications: Immunofluorescence, Western blot
Anti-MSH6 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10739 dilution 1:50.
Species: Human
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Immunohistochemical analysis of MSH6 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Species: Human, Monkey
Applications: IHC, IHC - Paraffin, ICC, Immunofluorescence, Western blot
Antibody
Species: Human
Applications: IHC, Immunofluorescence, Western blot, ELISA

Product Description

MSH6 antibody LS-C95606 is an unconjugated mouse monoclonal antibody to MSH6 from human, mouse, rat and other species. Validated for IP and WB.
About MSH6
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. P52701 NM_000179 NP_000170.1

MSH6 Antibody, GTBP Antibody, HSAP Antibody, GTMBP Antibody, MutS (E. coli) homolog 6 Antibody, HMSH6 Antibody, Sperm-associated protein Antibody, p160 Antibody, G/T mismatch-binding protein Antibody, HNPCC5 Antibody, MutS homolog 6 (E. coli) Antibody, MutS-alpha 160 kDa subunit Antibody


Specifications

Target
Human MSH6
Host
Mouse
Reactivity
Human, Mouse, Rat, Dog (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [44]
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Applications
  • Western blot (1:100 - 1:500)
  • Immunoprecipitation
Immunogen
MSH6 antibody was raised against synthetic human MSH6 peptide.
Specificity
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. cross reacts with mouse, rat and dog.
Presentation
0.05% sodium azide
Storage
Store at 2-8°C. Do not freeze.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/17/2018

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