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Anti-MSH6 Antibody (clone 44) LS-C95606

Catalog Size Price
LS-C95606-0.5 0.5 ml Unavailable
LS-C95606-1 1 ml Unavailable

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100% Guaranteed
Mouse Monoclonal [clone 44] (IgG1) to Human MSH6
Human, Mouse, Rat, Dog
Western blot, Immunoprecipitation
Unconjugated

Details

Human MSH6
Mouse
Human, Mouse, Rat, Dog (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [44]
Unconjugated
Purified
Unmodified

Applications

  • Western blot (1:100 - 1:500)
  • Immunoprecipitation

Specificity and Use

MSH6 antibody was raised against synthetic human MSH6 peptide.
MSH6 is a heterodimer of MSH2 and binds to DNA containing G/T mismatches. The MSH2-MSH6 complex recognizes a single-based mispair insertion/deletion loop. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related human carcinogenesis. Studies have shown the mutations of MLH-1, MSH2 and MSH6 genes contribute to the development of sporadic colorectal carcinoma. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. cross reacts with mouse, rat and dog.

Packaging

0.05% sodium azide
Store at 2°C to 8°C degrees. Do not freeze.
For research use only.

About MSH6

P52701 NM_000179 NP_000170.1

MSH6 Antibody, GTBP Antibody, HSAP Antibody, GTMBP Antibody, MutS (E. coli) homolog 6 Antibody, HMSH6 Antibody, Sperm-associated protein Antibody, p160 Antibody, G/T mismatch-binding protein Antibody, HNPCC5 Antibody, MutS homolog 6 (E. coli) Antibody, MutS-alpha 160 kDa subunit Antibody

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.

Requested From: 
Date Requested: 6/26/2017

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