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Anti-MSH2 Antibody (clone 25D12) LS-C95528

Catalog Size Price
LS-C95528-0.5 0.5 ml Unavailable
LS-C95528-1 1 ml Unavailable

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100% Guaranteed
Mouse Monoclonal [clone 25D12] (IgG1,k) to Human MSH2
IHC, IHC - Paraffin


Human MSH2
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [25D12]
Tissue culture supernatant


  • IHC
  • IHC - Paraffin

Specificity and Use

MSH2 antibody was raised against bALB/C mice were injected with recombinant human MSH2 protein.
Reacts with a 102 kD protein known as MSH2 (Mismatch Repair protein 2). MSH2 protein is involved in the initial recognition of mismatched nucleotides during the post replication mismatch repair process. Loss of MSH2 function leads to the accumulation of replication errors, which in turn may be responsible for the multiple mutations required for multistage carcinogenesis.


0.05% sodium azide
Store at 2-8°C. Do not freeze.
For research use only.

About MSH2

P43246 NM_000251 NP_000242.1

MSH2 Antibody, COCA1 Antibody, FCC1 Antibody, HNPCC Antibody, HNPCC1 Antibody, MutS protein homolog 2 Antibody, HMSH2 Antibody, LCFS2 Antibody

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.

Requested From: 
Date Requested: 5/21/2018

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