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Anti-MSH2 Antibody (aa550-600) IHC-plus™ LS-B1973

Note: This antibody replaces LS-C19338, LS-C72811
Catalog Size Price
LS-B1973-50 50 µg (0.5 mg/ml) Unavailable

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56 MSH2 Antibodies

Most Popular MSH2 Antibodies

Anti-MSH2 Antibody (aa550-600) IHC-plus™ LS-B1973
Rabbit Polyclonal to Human MSH2
Human, Mouse
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-MSH2 Antibody (clone 3A2B8C) LS-C82158
Mouse Monoclonal [clone 3A2B8C] (IgG1) to Human MSH2
Human
IHC - Paraffin, IHC - Frozen, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-MSH2 Antibody (Internal, clone SP46) LS-C210308
Rabbit Monoclonal [clone SP46] (IgG) to Human MSH2
Human
IHC - Paraffin, Flow Cytometry
Unconjugated
Immunohistochemistry Image
Anti-MSH2 Antibody (clone G219-1129) LS-C312104
Mouse Monoclonal [clone G219-1129] (IgG1) to Human MSH2
Human
IHC - Paraffin, IHC - Frozen
Unconjugated
Immunohistochemistry Image
Anti-MSH2 Antibody (clone 1B3) LS-C355354
Mouse Monoclonal [clone 1B3] (IgG1) to Human MSH2
Human, Primate
IHC, ICC, Immunofluorescence, Western blot
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Immunohistochemistry Image

100% Guaranteed
Rabbit Polyclonal to Human MSH2
Human, Mouse
IHC - Paraffin, Western blot
Unconjugated

Details

Human MSH2
Rabbit
Human, Mouse (tested or 100% immunogen sequence identity)
Polyclonal
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Western blot (1 - 3 µg/ml)

Specificity and Use

MSH2 antibody was raised against a portion of amino acids 550-600 of human MSH2.
aa550-600
The amino acid sequence used as immunogen is 100% homologous in human, dog and S. cerevisiae, 94% in mouse and rat, and 76% in zebrafish.
Immunohistochemistry: LS-B1973 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1973 was determined to be 5 ug/ml.

Packaging

PBS, 0.2% gelatin, 0.05% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

About MSH2

P43246 NM_000251 NP_000242.1

MSH2 Antibody, COCA1 Antibody, FCC1 Antibody, HNPCC Antibody, HNPCC1 Antibody, MutS protein homolog 2 Antibody, HMSH2 Antibody, LCFS2 Antibody

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA.

Immunohistochemistry

Immunohistochemistry
Anti-MSH2 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1973 concentration 5 ug/ml.

Western blot

Western blot
Western blot of MSH2 in HCT-116 using antibody at 2 ug/ml.

Requested From: 
Date Requested: 10/24/2017

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